Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood. We examined developmental variations between fetal/toddler and grownup livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to realize insights into the contribution of improvement to altered sterol metabolism and PNAC.
We used RNA-sequencing and computational strategies to check gene expression patterns in human fetal/toddler livers, grownup liver, and iHLC. We recognized distinct gene expression profiles between the human feta/toddler livers in comparison with grownup liver, and shut resemblance of iHLC to human creating livers. In comparison with grownup, each creating livers and iHLC had vital downregulation of xenobiotic, bile acid, and fatty acid metabolism; and decrease expression of the sterol metabolizing gene ABCG8.
When challenged with stigmasterol, a plant sterol present in intravenous soy lipids, lipid accumulation was considerably larger in iHLC in comparison with adult-derived HepG2 cells. Our findings present insights into altered bile acid and lipid metabolizing processes within the immature human liver, and assist using iHLC as a related mannequin system of creating liver to review lipid metabolism and PNAC.
Protecting Results of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Mixed with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Dying through Lowering the Ferroptosis of Hepatocytes
BACKGROUND To enhance the standard of liver grafts from extended-criteria donors donated after circulatory dying (DCD), this examine explored whether or not bone marrow mesenchymal stem cells (BMMSCs) mixed with normothermic machine perfusion (NMP) have protecting results on DCD donor livers and the results of ferroptosis on this process. MATERIAL AND METHODS Twenty-four male rat DCD donor livers have been randomly and averagely divided into regular, static chilly storage (SCS), NMP, and NMP mixed with BMMSCs teams. Liver operate, bile secretion, and pathological options of DCD donor livers have been detected to guage the protecting results of NMP and BMMSCs on DCD donor livers.
Hydrogen peroxide was used to induce an oxidative stress mannequin of hepatocyte IAR-20 cells to guage the protecting results of BMMSCs in vitro. RESULTS Livers handled with NMP mixed with BMMSCs confirmed higher liver operate, relieved histopathological injury, lowered oxidative stress harm and ferroptosis, and the mechanism of discount was related to downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ ranges.
BMMSCs confirmed vital protecting results on the ultrastructure of DCD donor livers and ROS-induced harm to IAR-20 cells underneath electron microscopy. BMMSCs additionally considerably improved the expression stage of microtubule-associated protein 1 gentle chain 3 (LC3)-II in each DCD donor livers and ROS-induced injured IAR-20 cells, together with upregulating the expression of ferritin. CONCLUSIONS BMMSCs mixed with NMP may cut back the extent of ROS and free Fe²⁺ in oxidative stress broken rat DCD donor livers, doubtlessly cut back the ferroptosis in hepatocytes, and restore each morphology and performance of DCD donor livers.
Therapeutic liver repopulation by transient acetaminophen choice of gene-modified hepatocytes
Gene remedy by integrating vectors is promising for monogenic liver illnesses, particularly in youngsters the place episomal vectors stay transient. Nonetheless, reaching the therapeutic threshold with genome-integrating vectors is difficult. Subsequently, we developed a way to develop hepatocytes bearing therapeutic transgenes. The frequent fever medication acetaminophen turns into hepatotoxic through cytochrome p450 metabolism. Lentiviral vectors with transgenes linked in cis to a Cypor shRNA have been administered to neonatal mice.
Hepatocytes missing the important cofactor of Cyp enzymes, NADPH-cytochrome p450 reductase (Cypor), have been chosen in vivo by acetaminophen administration, changing as much as 50% of the hepatic mass. Acetaminophen therapy of the mice resulted in over 30-fold growth of transgene-bearing hepatocytes and achieved therapeutic thresholds in hemophilia B and phenylketonuria. We conclude that therapeutically modified hepatocytes will be chosen safely and effectively in preclinical fashions with a transient routine of reasonably hepatotoxic acetaminophen.
Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells by way of the Nrf2-antioxidant response ingredient pathway
Non-alcoholic fatty liver illness (NAFLD) has develop into probably the most prevalent persistent liver illness globally. Aged people are at a better threat of creating NAFLD with extreme scientific outcomes. Though NAFLD is carefully associated to liver growing older, the position of hepatocyte senescence within the development of NAFLD, particularly within the improvement of fibrosis, continues to be unclear. The early stage of NAFLD is principally characterised by lipid accumulation in hepatocytes, which may result in extreme oxidative stress, inflicting mobile senescence.
Within the current examine, hepatocytes cultured within the presence of free fatty acids to induce lipid deposition have been used as a hepatocyte senescence mannequin in vitro. Senescent hepatocytes considerably elevated the activation of co-cultured major hepatic stellate cells (HSCs) and the expression of pro-fibrosis molecules. Furthermore, the antioxidant regulator nuclear issue erythroid 2-related issue 2 (Nrf2) that was upregulated in senescent hepatocytes was discovered to be associated to the activation of co-cultured HSCs.
 Male Cynomolgus monkey HEPATOCYTES in monolayer, in 12 well-plate |
|
LOCYF12-EU |
Westburg |
each |
Ask for price |
 Male Cynomolgus monkey HEPATOCYTES in monolayer, in 24 well-plate |
|
LOCYF24-EU |
Westburg |
each |
Ask for price |
 Male Cynomolgus monkey HEPATOCYTES in monolayer, in 48 well-plate |
|
LOCYF48-EU |
Westburg |
each |
Ask for price |
 Male Cynomolgus monkey HEPATOCYTESin monolayer, in 96 well-plate |
|
LOCYF96-EU |
Westburg |
each |
Ask for price |
 Cynomolgus HGF / Hepatocyte Growth Factor Protein |
|
G1017-.02 |
ApexBio |
20 µg |
EUR 560.4 |
 Hepatocytes, Plateable) Cryo Monkey (Cyno) Hepatocytes, Plateable |
|
LOCYCP01 |
Westburg |
each |
EUR 965.52 |
 Hepatocytes, Suspension) Cryo Monkey (Cyno) Hepatocytes, Suspension |
|
LOCYCS01 |
Westburg |
each |
EUR 517.8 |
 Hepatocytes, Plateable) Primary Dog (Beagle) Hepatocytes, Plateable |
|
T0118 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Plateable) Primary Rat (Fischer) Hepatocytes, Plateable |
|
T0108 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Dog (Beagle) Hepatocytes, Suspension |
|
T0117 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Normal Human Primary Plateable Hepatocytes |
|
T5539 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 925 |
Normal Human Primary Plateable Hepatocytes |
|
T5541 |
ABM |
1x10^6 cells / 1.0 ml |
Ask for price |
 Hepatocytes, Suspension) Primary Rat (Fischer) Hepatocytes, Suspension |
|
T0107 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Normal Human Primary Suspension Hepatocytes |
|
T5538 |
ABM |
1x10^6 cells / 1.0 ml |
Ask for price |
 Hepatocytes, Plateable) Primary Mouse (CD-1) Hepatocytes, Plateable |
|
T0120 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Mouse (CD-1) Hepatocytes, Suspension |
|
T0119 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Plateable) Primary Rat (Wistar Han) Hepatocytes, Plateable |
|
T0106 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Plateable) Primary Mouse (C57BI/6) Hepatocytes, Plateable |
|
T0122 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Minipig (Gottingen) Hepatocytes, Suspension |
|
T0113 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Rat (Wistar Han) Hepatocytes, Suspension |
|
T0105 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Mouse (C57BI/6) Hepatocytes, Suspension |
|
T0121 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Enhanced Primary Human Hepatocytes - 5 million |
|
T5996 |
ABM |
5x10^6 cells / 1.0 ml |
Ask for price |
 Hepatocytes, Plateable) Primary Rat (Sprague Dawley) Hepatocytes, Plateable |
|
T0104 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Rat (Sprague Dawley) Hepatocytes, Suspension |
|
T0103 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Enhanced Primary Human Hepatocytes – 1 Million |
|
T5995 |
ABM |
1x10^6 cells / 1.0ml |
Ask for price |
 Primary Human Hepatocytes, Transporter Uptake Qualified |
|
T0125 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 3500 |
 Primary Human Hepatocytes, Induction Qualified, Plateable |
|
T0128 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 2625 |
 Primary Human Hepatocytes, Metabolism Qualified, Plateable |
|
T0124 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 2625 |
 Immortalized Monkey Hepatocytes |
|
CSC-I2072Z |
Creative Bioarray |
One Frozen vial |
Ask for price |
 Primary Human Hepatocytes, Metabolism Qualified, Suspension |
|
T0123 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Hepatocytes, Suspension) Primary Rabbit (New Zealand White) Hepatocytes, Suspension |
|
T0115 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
 Immortalized Monkey Hepatocytes-SV40 |
|
T0073 |
ABM |
1x106 cells / 1.0 ml |
EUR 3950 |
 Serum, Monkey, Cynomolgus |
|
MBS638784-10mL |
MyBiosource |
10mL |
EUR 435 |
Serum, Monkey, Cynomolgus |
|
MBS638784-25mL |
MyBiosource |
25mL |
EUR 785 |
Serum, Monkey, Cynomolgus |
|
MBS638784-50mL |
MyBiosource |
50mL |
EUR 1320 |
Serum, Monkey, Cynomolgus |
|
MBS638784-5x50mL |
MyBiosource |
5x50mL |
EUR 5710 |
 Hepatocytes, Plateable) Cryo Monkey (Rhesus) Hepatocytes, Plateable |
|
LORHCP01 |
Westburg |
each |
EUR 965.52 |
 Monkey Eye cDNA-Random Primer, Cynomolgus |
|
KD-106-RH |
Zyagen |
30 reactions |
EUR 316 |
 Hepatocytes, Suspension) Cryo monkey (Rhesus) Hepatocytes, Suspension |
|
LORHCS01 |
Westburg |
each |
EUR 517.8 |
 Monkey Skin cDNA-Random Primer, Cynomolgus |
|
KD-101-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Lung cDNA-Random Primer, Cynomolgus |
|
KD-601-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Brain, cDNA-Random Primer, Cynomolgus |
|
KD-201-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Colon cDNA-Random Primer, Cynomolgus |
|
KD-311-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Liver cDNA-Random Primer, Cynomolgus |
|
KD-314-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Ovary cDNA-Random Primer, Cynomolgus |
|
KD-406-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Heart cDNA-Random Primer, Cynomolgus |
|
KD-801-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Aorta cDNA-Random Primer, Cynomolgus |
|
KD-807-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Tongue cDNA-Random Primer, Cynomolgus |
|
KD-105-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Rectum cDNA-Random Primer, Cynomolgus |
|
KD-312-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Testis cDNA-Random Primer, Cynomolgus |
|
KD-401-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Spleen cDNA-Random Primer, Cynomolgus |
|
KD-701-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Thymus cDNA-Random Primer, Cynomolgus |
|
KD-702-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Tonsil cDNA-Random Primer, Cynomolgus |
|
KD-707-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Artery cDNA-Random Primer, Cynomolgus |
|
KD-810-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Kidney cDNA-Random Primer, Cynomolgus |
|
KD-901-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Stomach cDNA-Random Primer, Cynomolgus |
|
KD-302-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Adrenal cDNA-Random Primer, Cynomolgus |
|
KD-501-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Thyroid cDNA-Random Primer, Cynomolgus |
|
KD-503-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Trachea cDNA-Random Primer, Cynomolgus |
|
KD-602-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Bladder cDNA-Random Primer, Cynomolgus |
|
KD-902-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Prostate cDNA-Random Primer, Cynomolgus |
|
KD-408-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Esophagus cDNA-Random Primer, Cynomolgus |
|
KD-301-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Pituitary cDNA-Random Primer, Cynomolgus |
|
KD-502-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Diaphragm cDNA-Random Primer, Cynomolgus |
|
KD-605-RH |
Zyagen |
30 reactions |
EUR 316 |
 Immortalized Monkey Hepatocytes-SV40 T+t |
|
T0074 |
ABM |
1x106 cells / 1.0 ml |
EUR 3950 |
 Monkey Epididymis cDNA-Random Primer, Cynomolgus |
|
KD-402-RH |
Zyagen |
30 reactions |
EUR 316 |
 Non-sterile Cynomolgus monkey plasma with heparin |
|
CMPH07-0050 |
Equitech |
50 ml |
EUR 1049.88 |
- Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.
|
Non-sterile Cynomolgus monkey plasma with heparin |
|
CMPH07-0100 |
Equitech |
100 ml |
EUR 1503.84 |
- Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.
|
Non-sterile Cynomolgus monkey plasma with heparin |
|
CMPH07-0500 |
Equitech |
500 ml |
Ask for price |
- Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.
|
 Monkey, Cynomolgus Genomic DNA |
|
GM-140C |
Zyagen |
0.1mg |
EUR 177 |
 Serum, Monkey, Cynomolgus, Female |
|
MBS638816-10mL |
MyBiosource |
10mL |
EUR 440 |
Serum, Monkey, Cynomolgus, Female |
|
MBS638816-25mL |
MyBiosource |
25mL |
EUR 870 |
Serum, Monkey, Cynomolgus, Female |
|
MBS638816-50mL |
MyBiosource |
50mL |
EUR 1350 |
Serum, Monkey, Cynomolgus, Female |
|
MBS638816-5x50mL |
MyBiosource |
5x50mL |
EUR 5845 |
 Monkey Lymph nodes cDNA-Random Primer, Cynomolgus |
|
KD-703-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Bone Marrow cDNA-Random Primer, Cynomolgus |
|
KD-704-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Eye cDNA, Cynomolgus |
|
KD-106 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Lung cDNA, Cynomolgus |
|
KD-601 |
Zyagen |
30 reactions |
EUR 316 |
 Adipose Lysate) Monkey (Cynomolgus) Adipose Lysate |
|
21-159 |
ProSci |
0.1 mg |
EUR 468.6 |
|
Description: Monkey (Cynomolgus) adipose tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Cynomolgus) adipose tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the adipose tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The adipose tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
 PLASMA in Sodium Heparin) OORA01345-10ML - MONKEY (Cynomolgus) PLASMA in Sodium Heparin |
|
OORA01345-10ML |
Aviva Systems Biology |
10mL |
EUR 1089 |
- MONKEY (Cynomolgus) PLASMA in Sodium Heparin
|
 Monkey Brain, cDNA, Cynomolgus |
|
KD-201 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Colon cDNA, Cynomolgus |
|
KD-311 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Liver cDNA, Cynomolgus |
|
KD-314 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Ovary cDNA, Cynomolgus |
|
KD-406 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Heart cDNA, Cynomolgus |
|
KD-801 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Aorta cDNA, Cynomolgus |
|
KD-807 |
Zyagen |
30 reactions |
EUR 446 |
 PLASMA in Lithium Heparin) OORA01469-10ML - MONKEY (Cynomolgus) PLASMA in Lithium Heparin |
|
OORA01469-10ML |
Aviva Systems Biology |
10mL |
EUR 1089 |
- MONKEY (Cynomolgus) PLASMA in Lithium Heparin
|
 Monkey Adipose Tissue cDNA-Random Primer, Cynomolgus |
|
KD-103-RH |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Salivary Gland, cDNA-Random Primer, Cynomolgus |
|
KD-317-RH |
Zyagen |
30 reactions |
EUR 316 |
 *Monkey Cynomolgus IgG ELISA Kit |
|
IMNCYIGGKT |
Innovative research |
each |
EUR 422 |
|
|
|
Description: *Monkey Cynomolgus IgG ELISA Kit |
 Monkey Tongue cDNA, Cynomolgus |
|
KD-105 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Rectum cDNA, Cynomolgus |
|
KD-312 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Testis cDNA, Cynomolgus |
|
KD-401 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Spleen cDNA, Cynomolgus |
|
KD-701 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Thymus cDNA, Cynomolgus |
|
KD-702 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Tonsil cDNA, Cynomolgus |
|
KD-707 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Artery cDNA, Cynomolgus |
|
KD-810 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Kidney cDNA, Cynomolgus |
|
KD-901 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Cynomolgus Albumin Purified |
|
IMNCYALB10MG |
Innovative research |
each |
EUR 215 |
|
|
|
Description: Monkey Cynomolgus Albumin Purified |
Monkey Cynomolgus Albumin Purified |
|
IMNCYALB25MG |
Innovative research |
each |
EUR 475 |
|
|
|
Description: Monkey Cynomolgus Albumin Purified |
Monkey Cynomolgus Albumin Purified |
|
IMNCYALB50MG |
Innovative research |
each |
EUR 920 |
|
|
|
Description: Monkey Cynomolgus Albumin Purified |
 Monkey Stomach cDNA, Cynomolgus |
|
KD-302 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Adrenal cDNA, Cynomolgus |
|
KD-501 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Thyroid cDNA, Cynomolgus |
|
KD-503 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Trachea cDNA, Cynomolgus |
|
KD-602 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Bladder cDNA, Cynomolgus |
|
KD-902 |
Zyagen |
30 reactions |
EUR 446 |
 Cynomolgus Monkey IL13 Protein |
|
E40PM131 |
EnoGene |
20ug |
EUR 495 |
 Cynomolgus Monkey TP53 Protein |
|
E40PM135 |
EnoGene |
20ug |
EUR 495 |
 Monkey Skeletal Muscles cDNA-Random Primer, Cynomolgus |
|
KD-102-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Seminal Vesicles cDNA-Random Primer, Cynomolgus |
|
KD-407-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Prostate cDNA, Cynomolgus |
|
KD-408 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Cynomolgus Skin Genomic DNA |
|
KG-101 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Lung Genomic DNA |
|
KG-601 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Esophagus cDNA, Cynomolgus |
|
KD-301 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Pituitary cDNA, Cynomolgus |
|
KD-502 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Diaphragm cDNA, Cynomolgus |
|
KD-605 |
Zyagen |
30 reactions |
EUR 316 |
 Cynomolgus Monkey IGFBP1 Protein |
|
E40PM143 |
EnoGene |
20ug |
EUR 495 |
 Monkey Cynomolgus Brain Genomic DNA |
|
KG-201 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Colon Genomic DNA |
|
KG-311 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Liver Genomic DNA |
|
KG-314 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Ovary Genomic DNA |
|
KG-406 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Heart Genomic DNA |
|
KG-801 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Epididymis cDNA, Cynomolgus |
|
KD-402 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Eye Total RNA, Cynomolgus |
|
KR-106 |
Zyagen |
0.025mg |
EUR 195 |
 Monkey Cynomolgus Testis Genomic DNA |
|
KG-401 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Uterus Genomic DNA |
|
KG-411 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Spleen Genomic DNA |
|
KG-701 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Kidney Genomic DNA |
|
KG-901 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Lung Tissue Lysate |
|
IMNCYLGTL100UG |
Innovative research |
each |
EUR 541 |
|
|
|
Description: Monkey Cynomolgus Lung Tissue Lysate |
 Monkey Cynomolgus Skin Tissue Lysate |
|
IMNCYSKNTL100UG |
Innovative research |
each |
EUR 804 |
|
|
|
Description: Monkey Cynomolgus Skin Tissue Lysate |
Monkey Cynomolgus Lung Tissue Lysate |
|
MBS8420208-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Monkey Cynomolgus Skin Tissue Lysate |
|
MBS8420210-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Monkey Skin Total RNA, Cynomolgus |
|
KR-101 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Lung Total RNA, Cynomolgus |
|
KR-601 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Cynomolgus Stomach Genomic DNA |
|
KG-302 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Colon Tissue Lysate |
|
IMNCYCLNTL100UG |
Innovative research |
each |
EUR 541 |
|
|
|
Description: Monkey Cynomolgus Colon Tissue Lysate |
Monkey Cynomolgus Colon Tissue Lysate |
|
MBS8420204-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Monkey Cynomolgus Pancreas Genomic DNA |
|
KG-313 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Kidney Tissue Lysate |
|
IMNCYKDTL100UG |
Innovative research |
each |
EUR 541 |
|
|
|
Description: Monkey Cynomolgus Kidney Tissue Lysate |
 Monkey Cynomolgus Spleen Tissue Lysate |
|
IMNCYSPTL100UG |
Innovative research |
each |
EUR 541 |
|
|
|
Description: Monkey Cynomolgus Spleen Tissue Lysate |
Monkey Cynomolgus Kidney Tissue Lysate |
|
MBS8420207-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Monkey Cynomolgus Spleen Tissue Lysate |
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MBS8420211-INQUIRE |
MyBiosource |
INQUIRE |
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 Monkey Brain Total RNA, Cynomolgus |
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KR-201 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Colon Total RNA, Cynomolgus |
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KR-311 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Liver Total RNA, Cynomolgus |
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KR-314 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Ovary Total RNA, Cynomolgus |
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KR-406 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Heart Total RNA, Cynomolgus |
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KR-801 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Aorta Total RNA, Cynomolgus |
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KR-807 |
Zyagen |
0.025mg |
EUR 260 |
 Monkey Cynomolgus Esophagus Genomic DNA |
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KG-301 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Intestine Genomic DNA |
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KG-306 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Cynomolgus Adipose Tissue Lysate |
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IMNCYADPTTL100UG |
Innovative research |
each |
EUR 804 |
|
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Description: Monkey Cynomolgus Adipose Tissue Lysate |
 *Monkey Cynomolgus IgG Affinity Purified |
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IMNCYIGGAP10MG |
Innovative research |
each |
EUR 300 |
|
|
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Description: *Monkey Cynomolgus IgG Affinity Purified |
*Monkey Cynomolgus IgG Affinity Purified |
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IMNCYIGGAP50MG |
Innovative research |
each |
EUR 706 |
|
|
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Description: *Monkey Cynomolgus IgG Affinity Purified |
Monkey Cynomolgus Adipose Tissue Lysate |
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MBS8420202-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Monkey Lymph nodes cDNA, Cynomolgus |
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KD-703 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Bone Marrow cDNA, Cynomolgus |
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KD-704 |
Zyagen |
30 reactions |
EUR 446 |
 Monkey Tongue Total RNA, Cynomolgus |
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KR-105 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Rectum Total RNA, Cynomolgus |
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KR-312 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Testis Total RNA, Cynomolgus |
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KR-401 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Spleen Total RNA, Cynomolgus |
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KR-701 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Thymus Total RNA, Cynomolgus |
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KR-702 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Tonsil Total RNA, Cynomolgus |
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KR-707 |
Zyagen |
0.05mg |
EUR 260 |
 Monkey Artery Total RNA, Cynomolgus |
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KR-810 |
Zyagen |
0.025mg |
EUR 260 |
 Monkey Kidney Total RNA, Cynomolgus |
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KR-901 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Small Intestine, Ileum cDNA-Random Primer, Cynomolgus |
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KD-309-RH |
Zyagen |
30 reactions |
EUR 316 |
 Methylated DNA Control) Monkey (Cynomolgus) Methylated DNA Control |
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D6534149-Cy |
Biochain |
5 ug |
Ask for price |
 Monkey Cynomolgus IgG1 Affinity Purified |
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IMNCYIGG1AP1000UG |
Innovative research |
each |
EUR 558 |
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Description: Monkey Cynomolgus IgG1 Affinity Purified |
Monkey Cynomolgus IgG1 Affinity Purified |
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IMNCYIGG1AP100UG |
Innovative research |
each |
EUR 206 |
|
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Description: Monkey Cynomolgus IgG1 Affinity Purified |
 SERUM) OORA01366-10ML - MONKEY (Cynomolgus) SERUM |
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OORA01366-10ML |
Aviva Systems Biology |
10mL |
EUR 1089 |
- MONKEY (Cynomolgus) SERUM
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 Cynomolgus Monkey CD3D & CD3E Protein |
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E40PM141 |
EnoGene |
20ug |
EUR 495 |
Cynomolgus Monkey CD3D & CD3E Protein |
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E40PM142 |
EnoGene |
20ug |
EUR 495 |
 Monkey Stomach Total RNA, Cynomolgus |
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KR-302 |
Zyagen |
0.1mg |
EUR 195 |
 Monkey Adrenal Total RNA, Cynomolgus |
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KR-501 |
Zyagen |
0.025mg |
EUR 260 |
 Monkey Thyroid Total RNA, Cynomolgus |
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KR-503 |
Zyagen |
0.025mg |
EUR 260 |
 Monkey Trachea Total RNA, Cynomolgus |
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KR-602 |
Zyagen |
0.05mg |
EUR 260 |
 Monkey Eye Total Protein, Cynomolgus |
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KT-106 |
Zyagen |
0.5mg |
EUR 176 |
 Monkey Prostate Total RNA, Cynomolgus |
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KR-408 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Lung Total Protein, Cynomolgus |
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KT-601 |
Zyagen |
1mg |
EUR 176 |
 Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron |
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SCMPH35-0050 |
Equitech |
50 ml |
EUR 1071.72 |
- Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.
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Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron |
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SCMPH35-0100 |
Equitech |
100 ml |
Ask for price |
- Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.
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Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron |
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SCMPH35-0500 |
Equitech |
500 ml |
Ask for price |
- Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.
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 Monkey Small Intestine, Jejunum cDNA-Random Primer, Cynomolgus |
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KD-308-RH |
Zyagen |
30 reactions |
EUR 316 |
 Non-sterile Cynomolgus monkey serum |
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CMS05-0050 |
Equitech |
50 ml |
EUR 889.2 |
- Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.
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Non-sterile Cynomolgus monkey serum |
|
CMS05-0100 |
Equitech |
100 ml |
EUR 1368.12 |
- Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.
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Non-sterile Cynomolgus monkey serum |
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CMS05-0500 |
Equitech |
500 ml |
Ask for price |
- Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.
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 Monkey Salivary Gland, cDNA, Cynomolgus |
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KD-317 |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Esophagus Total RNA, Cynomolgus |
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KR-301 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Pituitary Total RNA, Cynomolgus |
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KR-502 |
Zyagen |
0.025mg |
EUR 260 |
 Monkey Diaphragm Total RNA, Cynomolgus |
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KR-605 |
Zyagen |
0.05mg |
EUR 195 |
 Monkey Brain Total Protein, Cynomolgus |
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KT-201 |
Zyagen |
1mg |
EUR 176 |
 Monkey Colon Total Protein, Cynomolgus |
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KT-311 |
Zyagen |
1mg |
EUR 176 |
 Monkey Liver Total Protein, Cynomolgus |
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KT-314 |
Zyagen |
1mg |
EUR 176 |
 Monkey Heart Total Protein, Cynomolgus |
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KT-801 |
Zyagen |
1mg |
EUR 176 |
 Monkey Aorta Total Protein, Cynomolgus |
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KT-807 |
Zyagen |
0.5mg |
EUR 176 |
 Monkey Small Intestine, Duodenum cDNA-Random Primer, Cynomolgus |
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KD-307-RH |
Zyagen |
30 reactions |
EUR 316 |
 Monkey Cynomolgus Gallbladder Tissue Lysate |
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IMNCYGBTL100UG |
Innovative research |
each |
EUR 804 |
|
|
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Description: Monkey Cynomolgus Gallbladder Tissue Lysate |
Monkey Cynomolgus Gallbladder Tissue Lysate |
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MBS8420205-INQUIRE |
MyBiosource |
INQUIRE |
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 Normal Tissue: Lung) cDNA - Monkey (Cynomolgus) Normal Tissue: Lung |
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C1534152-Cy |
Biochain |
40 reactions |
EUR 353.5 |
 Normal Tissue: Skin) cDNA - Monkey (Cynomolgus) Normal Tissue: Skin |
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C1534218-Cy |
Biochain |
40 reactions |
EUR 353.5 |
The Nrf2 agonist sulforaphane, which upregulated the transcriptional exercise of the Nrf2-antioxidant response ingredient (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation impact on HSCs. Nonetheless, the liver tissue obtained from non-alcoholic steatohepatitis (NASH) mice with Nrf2 knockdown confirmed decreased antioxidation and vital liver senescence and fibrosis.
In conclusion, this examine confirmed that lipid accumulation induces hepatocyte senescence, which results in HSC activation and improvement of hepatic fibrosis. Growing the exercise of the Nrf2-ARE antioxidant pathway in senescent hepatocytes elicited the other impact, suggesting that focusing on Nrf2 might stop or delay the development of aging-related liver fibrosis in NASH.
