Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood. We examined developmental variations between fetal/toddler and grownup livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to realize insights into the contribution of improvement to altered sterol metabolism and PNAC.
We used RNA-sequencing and computational strategies to check gene expression patterns in human fetal/toddler livers, grownup liver, and iHLC. We recognized distinct gene expression profiles between the human feta/toddler livers in comparison with grownup liver, and shut resemblance of iHLC to human creating livers. In comparison with grownup, each creating livers and iHLC had vital downregulation of xenobiotic, bile acid, and fatty acid metabolism; and decrease expression of the sterol metabolizing gene ABCG8.
When challenged with stigmasterol, a plant sterol present in intravenous soy lipids, lipid accumulation was considerably larger in iHLC in comparison with adult-derived HepG2 cells. Our findings present insights into altered bile acid and lipid metabolizing processes within the immature human liver, and assist using iHLC as a related mannequin system of creating liver to review lipid metabolism and PNAC.

Protecting Results of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Mixed with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Dying through Lowering the Ferroptosis of Hepatocytes

BACKGROUND To enhance the standard of liver grafts from extended-criteria donors donated after circulatory dying (DCD), this examine explored whether or not bone marrow mesenchymal stem cells (BMMSCs) mixed with normothermic machine perfusion (NMP) have protecting results on DCD donor livers and the results of ferroptosis on this process. MATERIAL AND METHODS Twenty-four male rat DCD donor livers have been randomly and averagely divided into regular, static chilly storage (SCS), NMP, and NMP mixed with BMMSCs teams. Liver operate, bile secretion, and pathological options of DCD donor livers have been detected to guage the protecting results of NMP and BMMSCs on DCD donor livers.
 Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver
Hydrogen peroxide was used to induce an oxidative stress mannequin of hepatocyte IAR-20 cells to guage the protecting results of BMMSCs in vitro. RESULTS Livers handled with NMP mixed with BMMSCs confirmed higher liver operate, relieved histopathological injury, lowered oxidative stress harm and ferroptosis, and the mechanism of discount was related to downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ ranges.
BMMSCs confirmed vital protecting results on the ultrastructure of DCD donor livers and ROS-induced harm to IAR-20 cells underneath electron microscopy. BMMSCs additionally considerably improved the expression stage of microtubule-associated protein 1 gentle chain 3 (LC3)-II in each DCD donor livers and ROS-induced injured IAR-20 cells, together with upregulating the expression of ferritin. CONCLUSIONS BMMSCs mixed with NMP may cut back the extent of ROS and free Fe²⁺ in oxidative stress broken rat DCD donor livers, doubtlessly cut back the ferroptosis in hepatocytes, and restore each morphology and performance of DCD donor livers.

Therapeutic liver repopulation by transient acetaminophen choice of gene-modified hepatocytes

Gene remedy by integrating vectors is promising for monogenic liver illnesses, particularly in youngsters the place episomal vectors stay transient. Nonetheless, reaching the therapeutic threshold with genome-integrating vectors is difficult. Subsequently, we developed a way to develop hepatocytes bearing therapeutic transgenes. The frequent fever medication acetaminophen turns into hepatotoxic through cytochrome p450 metabolism. Lentiviral vectors with transgenes linked in cis to a Cypor shRNA have been administered to neonatal mice.
Hepatocytes missing the important cofactor of Cyp enzymes, NADPH-cytochrome p450 reductase (Cypor), have been chosen in vivo by acetaminophen administration, changing as much as 50% of the hepatic mass. Acetaminophen therapy of the mice resulted in over 30-fold growth of transgene-bearing hepatocytes and achieved therapeutic thresholds in hemophilia B and phenylketonuria. We conclude that therapeutically modified hepatocytes will be chosen safely and effectively in preclinical fashions with a transient routine of reasonably hepatotoxic acetaminophen.

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells by way of the Nrf2-antioxidant response ingredient pathway

Non-alcoholic fatty liver illness (NAFLD) has develop into probably the most prevalent persistent liver illness globally. Aged people are at a better threat of creating NAFLD with extreme scientific outcomes. Though NAFLD is carefully associated to liver growing older, the position of hepatocyte senescence within the development of NAFLD, particularly within the improvement of fibrosis, continues to be unclear. The early stage of NAFLD is principally characterised by lipid accumulation in hepatocytes, which may result in extreme oxidative stress, inflicting mobile senescence.
Within the current examine, hepatocytes cultured within the presence of free fatty acids to induce lipid deposition have been used as a hepatocyte senescence mannequin in vitro. Senescent hepatocytes considerably elevated the activation of co-cultured major hepatic stellate cells (HSCs) and the expression of pro-fibrosis molecules. Furthermore, the antioxidant regulator nuclear issue erythroid 2-related issue 2 (Nrf2) that was upregulated in senescent hepatocytes was discovered to be associated to the activation of co-cultured HSCs.

Primary Rat (Fischer) Hepatocytes, Plateable

T0108 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Suspension

T0117 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Fischer) Hepatocytes, Suspension

T0107 5x10^5 cells / 1.0 ml
EUR 1375

Normal Human Primary Plateable Hepatocytes

T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes

T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes

T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Plateable

T0106 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Suspension

T0105 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million

T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Plateable

T0104 5x10^5 cells / 1.0 ml
EUR 1375

Cynomolgus HGF / Hepatocyte Growth Factor Protein

G1017-.02 20 µg
EUR 560.4

Primary Rat (Sprague Dawley) Hepatocytes, Suspension

T0103 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml Ask for price

Biotinylated Recombinant Cynomolgus MSLN/Mesothelin Protein (Primary Amine Labeling)

RP02749 100μg
EUR 1423.5
  • Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glyc
  • Show more

Biotinylated Cynomolgus CD24 Protein, Fc Tag, ultra sensitivity (primary amine labeling)

CD4-C8254 25ug
EUR 1647.8
  • CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-ancho
  • Show more
Description: Biotinylated Cynomolgus CD24, Fc Tag, primary amine labeling (CD4-C8254) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Lys 54 (Accession # I7GKK1-1).

Non-sterile Cynomolgus monkey plasma with heparin

CMPH07-0050 50 ml
EUR 1049.88
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin

CMPH07-0100 100 ml
EUR 1503.84
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin

CMPH07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Monkey (Cynomolgus) Adipose Lysate

21-159 0.1 mg
EUR 468.6
Description: Monkey (Cynomolgus) adipose tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Cynomolgus) adipose tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the adipose tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The adipose tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

*Monkey Cynomolgus IgG ELISA Kit

IMNCYIGGKT each
EUR 422
  • Wet Ice
Description: *Monkey Cynomolgus IgG ELISA Kit

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml Ask for price

OORA01345-10ML - MONKEY (Cynomolgus) PLASMA in Sodium Heparin

OORA01345-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in Sodium Heparin

Monkey Cynomolgus Albumin Purified

IMNCYALB10MG each
EUR 215
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Monkey Cynomolgus Albumin Purified

IMNCYALB25MG each
EUR 475
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Monkey Cynomolgus Albumin Purified

IMNCYALB50MG each
EUR 920
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Cynomolgus Monkey IL13 Protein

E40PM131 20ug
EUR 495

Cynomolgus Monkey TP53 Protein

E40PM135 20ug
EUR 495

OORA01469-10ML - MONKEY (Cynomolgus) PLASMA in Lithium Heparin

OORA01469-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in Lithium Heparin

Cynomolgus Monkey IGFBP1 Protein

E40PM143 20ug
EUR 495

Monkey Cynomolgus Lung Tissue Lysate

IMNCYLGTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Lung Tissue Lysate

Monkey Cynomolgus Skin Tissue Lysate

IMNCYSKNTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Skin Tissue Lysate

Monkey Cynomolgus Colon Tissue Lysate

IMNCYCLNTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Colon Tissue Lysate

Monkey Cynomolgus Kidney Tissue Lysate

IMNCYKDTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Kidney Tissue Lysate

Monkey Cynomolgus Spleen Tissue Lysate

IMNCYSPTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Spleen Tissue Lysate

Monkey Cynomolgus Adipose Tissue Lysate

IMNCYADPTTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Adipose Tissue Lysate

*Monkey Cynomolgus IgG Affinity Purified

IMNCYIGGAP10MG each
EUR 300
  • Dry Ice
Description: *Monkey Cynomolgus IgG Affinity Purified

*Monkey Cynomolgus IgG Affinity Purified

IMNCYIGGAP50MG each
EUR 706
  • Dry Ice
Description: *Monkey Cynomolgus IgG Affinity Purified

Cynomolgus Monkey CD3D & CD3E Protein

E40PM141 20ug
EUR 495

Cynomolgus Monkey CD3D & CD3E Protein

E40PM142 20ug
EUR 495

Monkey (Cynomolgus) Methylated DNA Control

D6534149-Cy 5 ug Ask for price

OORA01366-10ML - MONKEY (Cynomolgus) SERUM

OORA01366-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) SERUM

Monkey Cynomolgus IgG1 Affinity Purified

IMNCYIGG1AP1000UG each
EUR 558
  • Dry Ice
Description: Monkey Cynomolgus IgG1 Affinity Purified

Monkey Cynomolgus IgG1 Affinity Purified

IMNCYIGG1AP100UG each
EUR 206
  • Dry Ice
Description: Monkey Cynomolgus IgG1 Affinity Purified

Biotinylated Cynomolgus Transferrin R / CD71 Protein, His Tag, ultra sensitivity (primary amine labeling)

TFR-C8249 25ug
EUR 1647.8
  • CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delive
  • Show more
Description: Biotinylated Cynomolgus Transferrin R, His Tag, primary amine labeling (TFR-C8249) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # G8F602-1). It is the biotinylated form of Cynomolgus Transferrin R, His Tag(Cat. No. TFR-C524a).

Biotinylated Recombinant Cynomolgus CD3E&CD3D/CD3 epsilon&CD3 delta Protein (Primary Amine Labeling)

RP02748 100μg
EUR 2843.75
  • T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell
  • Show more

Non-sterile Cynomolgus monkey serum

CMS05-0050 50 ml
EUR 889.2
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum

CMS05-0100 100 ml
EUR 1368.12
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum

CMS05-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron

SCMPH35-0050 50 ml
EUR 1071.72
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron

SCMPH35-0100 100 ml Ask for price
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron

SCMPH35-0500 500 ml Ask for price
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

cDNA - Monkey (Cynomolgus) Normal Tissue: Lung

C1534152-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Skin

C1534218-Cy 40 reactions
EUR 385

Monkey Cynomolgus Gallbladder Tissue Lysate

IMNCYGBTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Gallbladder Tissue Lysate

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain

C1534035-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Cecum

C1534089-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Colon

C1534090-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Heart

C1534122-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Liver

C1534149-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Ovary

C1534183-Cy 40 reactions
EUR 1049

cDNA - Monkey (Cynomolgus) Normal Tissue: Penis

C1534194-Cy 40 reactions
EUR 578

Monkey (Cynomolgus) cDNA Normal Tissue: Liver

MC34-149 10 rxn
EUR 498

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Cynomolgus Monkey EGFR Protein, His Tag

E40PM130 20ug
EUR 495

Cynomolgus Monkey KLRF1 Protein, Fc Tag

E40PM138 20ug
EUR 495

cDNA - Monkey (Cynomolgus) Normal Tissue: Kidney

C1534142-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Rectum

C1534206-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Spleen

C1534246-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Testis

C1534260-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Throat

C1534263-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Thymus

C1534264-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Tongue

C1534267-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Tonsil

C1534268-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Ureter

C1534273-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Uterus

C1534274-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Vagina

C1534283-Cy 40 reactions
EUR 578

Monkey (Cynomolgus) cDNA Normal Tissue: Spleen

MC34-246 10 rxn
EUR 498

Sterile filtered Cynomolgus monkey serum

SCM30-0025 25ml
EUR 723.84
  • Sterile filtered Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

cDNA - Monkey (Cynomolgus) Normal Tissue: Adipose

C1534003-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Adrenal

C1534004-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Bladder

C1534010-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Trachea

C1534160-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Parotid

C1534190-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Stomach

C1534248-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Thyroid

C1534265-Cy 40 reactions
EUR 578

Cynomolgus Monkey ACVRL1 Protein, Fc Tag

E40PM136 20ug
EUR 495

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Biotinylated Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, ultra sensitivity (primary amine labeling)

LA3-C8258 25ug
EUR 1647.8
  • Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intr
  • Show more
Description: Biotinylated Cynomolgus LAG-3, Mouse IgG2a Fc Tag, primary amine labeling (LA3-C8258) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - His 449 (Accession # XP_005570011.1).

*Monkey Cynomolgus Plasminogen Affinity Purified

IMNCYPLGAP10MG each
EUR 3638
  • Dry Ice
Description: *Monkey Cynomolgus Plasminogen Affinity Purified

*Monkey Cynomolgus Plasminogen Affinity Purified

IMNCYPLGAP1MG each
EUR 455
  • Dry Ice
Description: *Monkey Cynomolgus Plasminogen Affinity Purified

cDNA - Monkey (Cynomolgus) Normal Tissue: Appendix

C1534006-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Pancreas

C1534188-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Placenta

C1534200-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Prostate

C1534201-Cy 40 reactions
EUR 578

Monkey (Cynomolgus) control serum (IgG's-depleted)

NMCS-DG-1 1 ml
EUR 270

Monkey (Cynomolgus) cDNA Normal Tissue: Pancreas

MC34-188 10 rxn
EUR 498

Monkey Cynomolgus Gland Adrenal Tissue Lysate

IMNCYGLARTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Gland Adrenal Tissue Lysate

*Monkey (Cynomolgus) Total Plasminogen ELISA Kit

IMNCYPLGKTT each
EUR 528
  • Wet Ice
Description: *Monkey (Cynomolgus) Total Plasminogen ELISA Kit

Cynomolgus monkey IgG solution ? 97% purity

CM60-0100 100mg
EUR 2009.28
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Cynomolgus monkey IgG solution ? 97% purity

CM60-0500 500mg
EUR 7420.92
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Cynomolgus monkey IgG solution ? 97% purity

CM60-1000 1gm Ask for price
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Cynomolgus Monkey CD200R1 Protein, Fc Tag

E40PM133 20ug
EUR 495

Cynomolgus Monkey ACVRL1 Protein, His Tag

E40PM137 20ug
EUR 495

Cynomolgus Monkey PTGFRN Protein, His Tag

E40PM139 20ug
EUR 495

cDNA - Monkey (Cynomolgus) Normal Tissue: Esophagus

C1534106-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Diaphragm

C1534169-Cy 40 reactions
EUR 578

Cynomolgus Monkey CD200R1 Protein, His Tag

E40PM132 20ug
EUR 495

Cynomolgus Monkey CD200R1 Protein, His Tag

E40PM134 20ug
EUR 495

*Monkey (Cynomolgus) Total Factor VIII ELISA Kit

IMNCYFVIIIKTT each
EUR 528
  • Wet Ice
Description: *Monkey (Cynomolgus) Total Factor VIII ELISA Kit

Monkey Serum Albumin, Cynomolgus, Lyophilized

22070094-1 50 mg
EUR 1094.44

Monkey Serum Albumin, Cynomolgus, Lyophilized

22070094-2 100 mg
EUR 1816.43

Cynomolgus Monkey Cardiac Endothelial Cells

ABC-TC3393 1 vial Ask for price
  • For research use only
Description: Monkey Cardiac Endothelial Cells from Gentaur are isolated from tissue of Cynomolgus Monkey. Monkey Cardiac Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Gentaur's Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen.Monkey Cardiac Endothelial Cells can be used in assays of cell to cell adhesion, migration, vascular tube formation. Standard biochemical procedures performed with endothelial cell cultures include RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

cDNA - Monkey (Cynomolgus) Normal Tissue: Epididymis

C1534105-Cy 40 reactions
EUR 578

Monkey Cynomolgus Skeletal Muscle Tissue Lysate

IMNCYSKMTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Skeletal Muscle Tissue Lysate

Control Genomic DNA - Cynomolgus Monkey Male

D1534999-Cy-G01 100 ug
EUR 170

cDNA - Monkey (Cynomolgus) Normal Tissue: Whole Eye

C1534108-Cy 40 reactions
EUR 578

Total RNA - Monkey (Cynomolgus) Normal Tissue: Lung

R1534152-Cy 50 ug
EUR 191

cDNA - Monkey (Cynomolgus) Normal Tissue: Gallbladder

C1534118-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Parathyroid

C1534189-Cy 40 reactions
EUR 1180

Monkey Cynomolgus Brain Lysate Membrane Fraction

IMNCYBRTLM100UG each
EUR 1199
  • Wet Ice
Description: Monkey Cynomolgus Brain Lysate Membrane Fraction

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Pons

C1534071-Cy 40 reactions
EUR 578

Total RNA - Monkey (Cynomolgus) Normal Tissue: Brain

R1534035-Cy 50 ug
EUR 191

Total RNA - Monkey (Cynomolgus) Normal Tissue: Colon

R1534090-Cy 50 ug
EUR 191

Total RNA - Monkey (Cynomolgus) Normal Tissue: Heart

R1534122-Cy 50 ug
EUR 191

Total RNA - Monkey (Cynomolgus) Normal Tissue: Liver

R1534149-Cy 50 ug
EUR 191

cDNA - Monkey (Cynomolgus) Normal Tissue: Spinal Cord

C1534234-Cy 40 reactions
EUR 578

OORA01460-10ML - MONKEY (Cynomolgus) PLASMA in ACD

OORA01460-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in ACD

Total RNA - Monkey (Cynomolgus) Normal Tissue: Artery

R1534013-Cy 50 ug
EUR 353

Total RNA - Monkey (Cynomolgus) Normal Tissue: Kidney

R1534142-Cy 50 ug
EUR 191

Control Genomic DNA - Cynomolgus Monkey Female

D1534999-Cy-G02 100 ug
EUR 170

Cynomolgus Monkey FCGRT & B2M Protein, His Tag

E40PM140 20ug
EUR 495

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain:Cerebellum

C1534039-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Insula

C1534055-Cy 40 reactions
EUR 578

Total RNA - Monkey (Cynomolgus) Normal Tissue: Bladder

R1534010-Cy 50 ug
EUR 353

Total RNA - Monkey (Cynomolgus) Normal Tissue: Stomach

R1534248-Cy 50 ug
EUR 191

cDNA - Monkey (Cynomolgus) Normal Tissue: Uterus: Cervix

C1534275-Cy 40 reactions
EUR 578

Total RNA - Monkey (Cynomolgus) Normal Tissue: Pancreas

R1534188-Cy 50 ug
EUR 191

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER15ML each
EUR 364
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

Innovative Grade US Origin Monkey Cynomolgus Serum

IGMNCYSER5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Serum

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Amygdala

C1534036-Cy 40 reactions
EUR 578

Total RNA - Monkey (Cynomolgus) Normal Tissue: Diaphragm

R1534169-Cy 50 ug
EUR 191

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK2E100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK2E10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK2E25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK2E50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK2E5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK3E100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK3E10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK3E25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK3E50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLAK3E5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLALIH100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLALIH10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLALIH25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLALIH50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLALIH5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAC100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAC10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAC25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAC50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAC5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAE100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAE10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAE25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAE50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAE5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAH100ML each
EUR 1434
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAH10ML each
EUR 296
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAH25ML each
EUR 425
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAH50ML each
EUR 745
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

Innovative Grade US Origin Monkey Cynomolgus Plasma

IGMNCYPLANAH5ML each
EUR 214
  • Dry Ice
Description: Innovative Grade US Origin Monkey Cynomolgus Plasma

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Olfactory

C1534063-Cy 40 reactions
EUR 578

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Pituitary

C1534068-Cy 40 reactions
EUR 715

cDNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle

C1534171-Cy 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Small Intestine

C1534226-Cy 40 reactions
EUR 578

Non-sterile Cynomolgus monkey plasma with EDT

CMPE07-0050 50 ml
EUR 1049.88
  • Non-sterile Cynomolgus monkey plasma with EDT is indicated as RUO. Do not use on humans.

OORA01225-10ML - MONKEY (Cynomolgus) PLASMA in Alsevers

OORA01225-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in Alsevers

cDNA - Monkey (Cynomolgus) Normal Tissue: Liver: Left Lobe

C1534150-Cy 40 reactions
EUR 385

Non-sterile Cynomolgus monkey plasma with EDTA

CMPE07-0100 100 ml
EUR 1503.84
  • Non-sterile Cynomolgus monkey plasma with EDTA is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with EDTA

CMPE07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with EDTA is indicated as RUO. Do not use on humans.

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Hippocampus

C1534052-Cy 40 reactions
EUR 715

cDNA - Monkey (Cynomolgus) Normal Tissue: Heart: Pericardium

C1534133-Cy 40 reactions
EUR 578

Membrane Protein - Monkey (Cynomolgus) Normal Tissue: Brain

P3534035-Cy 0.1 mg
EUR 270
The Nrf2 agonist sulforaphane, which upregulated the transcriptional exercise of the Nrf2-antioxidant response ingredient (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation impact on HSCs. Nonetheless, the liver tissue obtained from non-alcoholic steatohepatitis (NASH) mice with Nrf2 knockdown confirmed decreased antioxidation and vital liver senescence and fibrosis.
In conclusion, this examine confirmed that lipid accumulation induces hepatocyte senescence, which results in HSC activation and improvement of hepatic fibrosis. Growing the exercise of the Nrf2-ARE antioxidant pathway in senescent hepatocytes elicited the other impact, suggesting that focusing on Nrf2 might stop or delay the development of aging-related liver fibrosis in NASH.
Source : Gentaur

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