Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

June 24, 2021 Leave a comment
Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood. We examined developmental variations between fetal/toddler and grownup livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to realize insights into the contribution of improvement to altered sterol metabolism and PNAC.
We used RNA-sequencing and computational strategies to check gene expression patterns in human fetal/toddler livers, grownup liver, and iHLC. We recognized distinct gene expression profiles between the human feta/toddler livers in comparison with grownup liver, and shut resemblance of iHLC to human creating livers. In comparison with grownup, each creating livers and iHLC had vital downregulation of xenobiotic, bile acid, and fatty acid metabolism; and decrease expression of the sterol metabolizing gene ABCG8.
When challenged with stigmasterol, a plant sterol present in intravenous soy lipids, lipid accumulation was considerably larger in iHLC in comparison with adult-derived HepG2 cells. Our findings present insights into altered bile acid and lipid metabolizing processes within the immature human liver, and assist using iHLC as a related mannequin system of creating liver to review lipid metabolism and PNAC.

Protecting Results of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Mixed with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Dying through Lowering the Ferroptosis of Hepatocytes

BACKGROUND To enhance the standard of liver grafts from extended-criteria donors donated after circulatory dying (DCD), this examine explored whether or not bone marrow mesenchymal stem cells (BMMSCs) mixed with normothermic machine perfusion (NMP) have protecting results on DCD donor livers and the results of ferroptosis on this process. MATERIAL AND METHODS Twenty-four male rat DCD donor livers have been randomly and averagely divided into regular, static chilly storage (SCS), NMP, and NMP mixed with BMMSCs teams. Liver operate, bile secretion, and pathological options of DCD donor livers have been detected to guage the protecting results of NMP and BMMSCs on DCD donor livers.
Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver
Hydrogen peroxide was used to induce an oxidative stress mannequin of hepatocyte IAR-20 cells to guage the protecting results of BMMSCs in vitro. RESULTS Livers handled with NMP mixed with BMMSCs confirmed higher liver operate, relieved histopathological injury, lowered oxidative stress harm and ferroptosis, and the mechanism of discount was related to downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ ranges.
BMMSCs confirmed vital protecting results on the ultrastructure of DCD donor livers and ROS-induced harm to IAR-20 cells underneath electron microscopy. BMMSCs additionally considerably improved the expression stage of microtubule-associated protein 1 gentle chain 3 (LC3)-II in each DCD donor livers and ROS-induced injured IAR-20 cells, together with upregulating the expression of ferritin. CONCLUSIONS BMMSCs mixed with NMP may cut back the extent of ROS and free Fe²⁺ in oxidative stress broken rat DCD donor livers, doubtlessly cut back the ferroptosis in hepatocytes, and restore each morphology and performance of DCD donor livers.

Therapeutic liver repopulation by transient acetaminophen choice of gene-modified hepatocytes

Gene remedy by integrating vectors is promising for monogenic liver illnesses, particularly in youngsters the place episomal vectors stay transient. Nonetheless, reaching the therapeutic threshold with genome-integrating vectors is difficult. Subsequently, we developed a way to develop hepatocytes bearing therapeutic transgenes. The frequent fever medication acetaminophen turns into hepatotoxic through cytochrome p450 metabolism. Lentiviral vectors with transgenes linked in cis to a Cypor shRNA have been administered to neonatal mice.
Hepatocytes missing the important cofactor of Cyp enzymes, NADPH-cytochrome p450 reductase (Cypor), have been chosen in vivo by acetaminophen administration, changing as much as 50% of the hepatic mass. Acetaminophen therapy of the mice resulted in over 30-fold growth of transgene-bearing hepatocytes and achieved therapeutic thresholds in hemophilia B and phenylketonuria. We conclude that therapeutically modified hepatocytes will be chosen safely and effectively in preclinical fashions with a transient routine of reasonably hepatotoxic acetaminophen.

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells by way of the Nrf2-antioxidant response ingredient pathway

Non-alcoholic fatty liver illness (NAFLD) has develop into probably the most prevalent persistent liver illness globally. Aged people are at a better threat of creating NAFLD with extreme scientific outcomes. Though NAFLD is carefully associated to liver growing older, the position of hepatocyte senescence within the development of NAFLD, particularly within the improvement of fibrosis, continues to be unclear. The early stage of NAFLD is principally characterised by lipid accumulation in hepatocytes, which may result in extreme oxidative stress, inflicting mobile senescence.
Within the current examine, hepatocytes cultured within the presence of free fatty acids to induce lipid deposition have been used as a hepatocyte senescence mannequin in vitro. Senescent hepatocytes considerably elevated the activation of co-cultured major hepatic stellate cells (HSCs) and the expression of pro-fibrosis molecules. Furthermore, the antioxidant regulator nuclear issue erythroid 2-related issue 2 (Nrf2) that was upregulated in senescent hepatocytes was discovered to be associated to the activation of co-cultured HSCs.

Anti-Hepatocytes antibody
STJ16100176 100 µg
EUR 389

Sterile filtered Cynomolgus monkey serum
SCM30-0025 25ml
EUR 603.2
  • Sterile filtered Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0050 50 ml
EUR 741
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0100 100 ml
EUR 1140.1
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Genomic DNA - Cynomolgus Monkey Male
D1534999-Cy-G01 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Cynomolgus Monkey Female
D1534999-Cy-G02 100 ug
EUR 188
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Monkey (Cynomolgus) Methylated DNA Control
D6534149-Cy 5 ug Ask for price
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Primary hepatic carcinoma ELISA kit
E09P0656-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat
4-20302 ea Ask for price

Human Hepatocytes - Alcohol Addicted
HC4230AA 500,000 Cells
EUR 957

Human Hepatocytes - Opioid Addicted
HC4230OP 500000
EUR 957

Mouse Liver PrimaCell: Hepatocytes
2-82100 1 Kit Ask for price

Rat Liver PrimaCell: Hepatocytes
2-82595 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes
2-96121 1 Kit Ask for price

Immortalized Human Hepatocytes - hTERT
T0058 1x106 cells / 1.0 ml Ask for price

Immortalized Human Hepatocytes - Ras
T0059 1x106 cells / 1.0 ml Ask for price

Immortalized Rat Hepatocytes - SV40
T0078 1x106 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes - SV40
T0101 1x106 cells / 1.0 ml Ask for price

Monkey (Cynomolgus) control serum (IgG's-depleted)
NMCS-DG-1 1 ml
EUR 225

Monkey (Cynomolgus) cDNA Normal Tissue: Liver
MC34-149 10 rxn
EUR 415

Monkey (Cynomolgus) cDNA Normal Tissue: Pancreas
MC34-188 10 rxn
EUR 415

Monkey (Cynomolgus) cDNA Normal Tissue: Spleen
MC34-246 10 rxn
EUR 415

Cynomolgus monkey IgG solution ? 97% purity
CM60-0100 100mg
EUR 1674.4
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Cynomolgus monkey IgG solution ? 97% purity
CM60-0500 500mg
EUR 6184.1
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Cynomolgus monkey IgG solution ? 97% purity
CM60-1000 1gm Ask for price
  • Cynomolgus monkey IgG solution ? 97% purity is indicated as RUO. Do not use on humans.

Immortalized Mouse Hepatocytes-Conditionally (ImHep)
T0099 1x106 cells / 1.0 ml Ask for price

Sterile filtered Cynomolgus monkey serum, 0.2 micron
SCM30-0050 50 ml
EUR 893.1
  • Sterile filtered Cynomolgus monkey serum, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey serum, 0.2 micron
SCM30-0100 100 ml Ask for price
  • Sterile filtered Cynomolgus monkey serum, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey serum, 0.2 micron
SCM30-0500 500 ml Ask for price
  • Sterile filtered Cynomolgus monkey serum, 0.2 micron is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with EDT
CMPE07-0050 50 ml
EUR 874.9
  • Non-sterile Cynomolgus monkey plasma with EDT is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with EDTA
CMPE07-0100 100 ml
EUR 1253.2
  • Non-sterile Cynomolgus monkey plasma with EDTA is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with EDTA
CMPE07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with EDTA is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0050 50 ml
EUR 874.9
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0100 100 ml
EUR 1253.2
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

cDNA from Monkey (Cynomolgus) Normal Tissue: Adipose
C1534003-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Adrenal
C1534004-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Appendix
C1534006-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Bladder
C1534010-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain
C1534035-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain:Cerebellum
C1534039-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Cecum
C1534089-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Colon
C1534090-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Epididymis
C1534105-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Esophagus
C1534106-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Gallbladder
C1534118-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Heart
C1534122-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Kidney
C1534142-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Liver
C1534149-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Lung
C1534152-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Trachea
C1534160-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Diaphragm
C1534169-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Ovary
C1534183-Cy 40 reactions
EUR 939
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Pancreas
C1534188-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Parathyroid
C1534189-Cy 40 reactions
EUR 1051
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Parotid
C1534190-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Penis
C1534194-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Placenta
C1534200-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Prostate
C1534201-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Rectum
C1534206-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Skin
C1534218-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Spleen
C1534246-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Stomach
C1534248-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Testis
C1534260-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Throat
C1534263-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Thymus
C1534264-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Thyroid
C1534265-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Tongue
C1534267-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Tonsil
C1534268-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Ureter
C1534273-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Uterus
C1534274-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Vagina
C1534283-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Non-sterile Cynomolgus monkey plasma with sodium citrate
CMPC07-0050 50 ml
EUR 874.9
  • Non-sterile Cynomolgus monkey plasma with sodium citrate is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with sodium citrate
CMPC07-0100 100 ml
EUR 1253.2
  • Non-sterile Cynomolgus monkey plasma with sodium citrate is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with sodium citrate
CMPC07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with sodium citrate is indicated as RUO. Do not use on humans.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Amygdala
C1534036-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Diencephalon
C1534049-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Hippocampus
C1534052-Cy 40 reactions
EUR 656
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Insula
C1534055-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Olfactory
C1534063-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Pituitary
C1534068-Cy 40 reactions
EUR 656
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Pons
C1534071-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Whole Eye
C1534108-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Heart: Pericardium
C1534133-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle
C1534171-Cy 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Small Intestine
C1534226-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Spinal Cord
C1534234-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Uterus: Cervix
C1534275-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Membrane Protein from Monkey (Cynomolgus) Normal Tissue: Brain
P3534035-Cy 0.1 mg
EUR 285
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Bladder
R1534010-Cy 50 ug
EUR 316
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Artery
R1534013-Cy 50 ug
EUR 316
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Brain
R1534035-Cy 50 ug
EUR 194
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Colon
R1534090-Cy 50 ug
EUR 194
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
The Nrf2 agonist sulforaphane, which upregulated the transcriptional exercise of the Nrf2-antioxidant response ingredient (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation impact on HSCs. Nonetheless, the liver tissue obtained from non-alcoholic steatohepatitis (NASH) mice with Nrf2 knockdown confirmed decreased antioxidation and vital liver senescence and fibrosis.
In conclusion, this examine confirmed that lipid accumulation induces hepatocyte senescence, which results in HSC activation and improvement of hepatic fibrosis. Growing the exercise of the Nrf2-ARE antioxidant pathway in senescent hepatocytes elicited the other impact, suggesting that focusing on Nrf2 might stop or delay the development of aging-related liver fibrosis in NASH.
Source : Gentaur

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