Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

June 24, 2021 Leave a comment
Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood. We examined developmental variations between fetal/toddler and grownup livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to realize insights into the contribution of improvement to altered sterol metabolism and PNAC.
We used RNA-sequencing and computational strategies to check gene expression patterns in human fetal/toddler livers, grownup liver, and iHLC. We recognized distinct gene expression profiles between the human feta/toddler livers in comparison with grownup liver, and shut resemblance of iHLC to human creating livers. In comparison with grownup, each creating livers and iHLC had vital downregulation of xenobiotic, bile acid, and fatty acid metabolism; and decrease expression of the sterol metabolizing gene ABCG8.
When challenged with stigmasterol, a plant sterol present in intravenous soy lipids, lipid accumulation was considerably larger in iHLC in comparison with adult-derived HepG2 cells. Our findings present insights into altered bile acid and lipid metabolizing processes within the immature human liver, and assist using iHLC as a related mannequin system of creating liver to review lipid metabolism and PNAC.

Protecting Results of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Mixed with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Dying through Lowering the Ferroptosis of Hepatocytes

BACKGROUND To enhance the standard of liver grafts from extended-criteria donors donated after circulatory dying (DCD), this examine explored whether or not bone marrow mesenchymal stem cells (BMMSCs) mixed with normothermic machine perfusion (NMP) have protecting results on DCD donor livers and the results of ferroptosis on this process. MATERIAL AND METHODS Twenty-four male rat DCD donor livers have been randomly and averagely divided into regular, static chilly storage (SCS), NMP, and NMP mixed with BMMSCs teams. Liver operate, bile secretion, and pathological options of DCD donor livers have been detected to guage the protecting results of NMP and BMMSCs on DCD donor livers.
Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver
Hydrogen peroxide was used to induce an oxidative stress mannequin of hepatocyte IAR-20 cells to guage the protecting results of BMMSCs in vitro. RESULTS Livers handled with NMP mixed with BMMSCs confirmed higher liver operate, relieved histopathological injury, lowered oxidative stress harm and ferroptosis, and the mechanism of discount was related to downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ ranges.
BMMSCs confirmed vital protecting results on the ultrastructure of DCD donor livers and ROS-induced harm to IAR-20 cells underneath electron microscopy. BMMSCs additionally considerably improved the expression stage of microtubule-associated protein 1 gentle chain 3 (LC3)-II in each DCD donor livers and ROS-induced injured IAR-20 cells, together with upregulating the expression of ferritin. CONCLUSIONS BMMSCs mixed with NMP may cut back the extent of ROS and free Fe²⁺ in oxidative stress broken rat DCD donor livers, doubtlessly cut back the ferroptosis in hepatocytes, and restore each morphology and performance of DCD donor livers.

Therapeutic liver repopulation by transient acetaminophen choice of gene-modified hepatocytes

Gene remedy by integrating vectors is promising for monogenic liver illnesses, particularly in youngsters the place episomal vectors stay transient. Nonetheless, reaching the therapeutic threshold with genome-integrating vectors is difficult. Subsequently, we developed a way to develop hepatocytes bearing therapeutic transgenes. The frequent fever medication acetaminophen turns into hepatotoxic through cytochrome p450 metabolism. Lentiviral vectors with transgenes linked in cis to a Cypor shRNA have been administered to neonatal mice.
Hepatocytes missing the important cofactor of Cyp enzymes, NADPH-cytochrome p450 reductase (Cypor), have been chosen in vivo by acetaminophen administration, changing as much as 50% of the hepatic mass. Acetaminophen therapy of the mice resulted in over 30-fold growth of transgene-bearing hepatocytes and achieved therapeutic thresholds in hemophilia B and phenylketonuria. We conclude that therapeutically modified hepatocytes will be chosen safely and effectively in preclinical fashions with a transient routine of reasonably hepatotoxic acetaminophen.

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells by way of the Nrf2-antioxidant response ingredient pathway

Non-alcoholic fatty liver illness (NAFLD) has develop into probably the most prevalent persistent liver illness globally. Aged people are at a better threat of creating NAFLD with extreme scientific outcomes. Though NAFLD is carefully associated to liver growing older, the position of hepatocyte senescence within the development of NAFLD, particularly within the improvement of fibrosis, continues to be unclear. The early stage of NAFLD is principally characterised by lipid accumulation in hepatocytes, which may result in extreme oxidative stress, inflicting mobile senescence.
Within the current examine, hepatocytes cultured within the presence of free fatty acids to induce lipid deposition have been used as a hepatocyte senescence mannequin in vitro. Senescent hepatocytes considerably elevated the activation of co-cultured major hepatic stellate cells (HSCs) and the expression of pro-fibrosis molecules. Furthermore, the antioxidant regulator nuclear issue erythroid 2-related issue 2 (Nrf2) that was upregulated in senescent hepatocytes was discovered to be associated to the activation of co-cultured HSCs.

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 12 well-plate
LOCYF12-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 24 well-plate
LOCYF24-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 48 well-plate
LOCYF48-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTESin monolayer, in 96 well-plate
LOCYF96-EU each Ask for price

Primary Dog (Beagle) Hepatocytes, Plateable
T0118 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Suspension
T0117 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Fischer) Hepatocytes, Plateable
T0108 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Fischer) Hepatocytes, Suspension
T0107 5x10^5 cells / 1.0 ml
EUR 1375

Normal Human Primary Plateable Hepatocytes
T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes
T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes
T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable
T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension
T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable
T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Plateable
T0106 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension
T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension
T0121 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Suspension
T0105 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million
T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Rat (Sprague Dawley) Hepatocytes, Plateable
T0104 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Suspension
T0103 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes – 1 Million
T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified
T0125 5x10^5 cells / 1.0 ml
EUR 3500

Primary Human Hepatocytes, Induction Qualified, Plateable
T0128 5x10^5 cells / 1.0 ml
EUR 2625

Cynomolgus HGF / Hepatocyte Growth Factor Protein
G1017-.02 20 µg
EUR 560.4

Primary Human Hepatocytes, Metabolism Qualified, Plateable
T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension
T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension
T0115 5x10^5 cells / 1.0 ml
EUR 1375

Cryo Monkey (Cyno) Hepatocytes, Plateable
LOCYCP01 each
EUR 965.52

Cryo Monkey (Cyno) Hepatocytes, Suspension
LOCYCS01 each
EUR 517.8

Immortalized Monkey Hepatocytes
CSC-I2072Z One Frozen vial Ask for price

Monkey Eye cDNA-Random Primer, Cynomolgus
KD-106-RH 30 reactions
EUR 316

Immortalized Monkey Hepatocytes-SV40
T0073 1x106 cells / 1.0 ml
EUR 3950

Monkey Skin cDNA-Random Primer, Cynomolgus
KD-101-RH 30 reactions
EUR 316

Monkey Lung cDNA-Random Primer, Cynomolgus
KD-601-RH 30 reactions
EUR 316

Monkey Brain, cDNA-Random Primer, Cynomolgus
KD-201-RH 30 reactions
EUR 316

Monkey Colon cDNA-Random Primer, Cynomolgus
KD-311-RH 30 reactions
EUR 316

Monkey Liver cDNA-Random Primer, Cynomolgus
KD-314-RH 30 reactions
EUR 316

Monkey Ovary cDNA-Random Primer, Cynomolgus
KD-406-RH 30 reactions
EUR 316

Monkey Heart cDNA-Random Primer, Cynomolgus
KD-801-RH 30 reactions
EUR 316

Monkey Aorta cDNA-Random Primer, Cynomolgus
KD-807-RH 30 reactions
EUR 446

Monkey Tongue cDNA-Random Primer, Cynomolgus
KD-105-RH 30 reactions
EUR 316

Monkey Rectum cDNA-Random Primer, Cynomolgus
KD-312-RH 30 reactions
EUR 316

Monkey Testis cDNA-Random Primer, Cynomolgus
KD-401-RH 30 reactions
EUR 316

Monkey Spleen cDNA-Random Primer, Cynomolgus
KD-701-RH 30 reactions
EUR 316

Monkey Thymus cDNA-Random Primer, Cynomolgus
KD-702-RH 30 reactions
EUR 316

Monkey Tonsil cDNA-Random Primer, Cynomolgus
KD-707-RH 30 reactions
EUR 446

Monkey Artery cDNA-Random Primer, Cynomolgus
KD-810-RH 30 reactions
EUR 446

Monkey Kidney cDNA-Random Primer, Cynomolgus
KD-901-RH 30 reactions
EUR 316

Monkey Stomach cDNA-Random Primer, Cynomolgus
KD-302-RH 30 reactions
EUR 316

Monkey Adrenal cDNA-Random Primer, Cynomolgus
KD-501-RH 30 reactions
EUR 446

Monkey Thyroid cDNA-Random Primer, Cynomolgus
KD-503-RH 30 reactions
EUR 446

Monkey Trachea cDNA-Random Primer, Cynomolgus
KD-602-RH 30 reactions
EUR 446

Monkey Bladder cDNA-Random Primer, Cynomolgus
KD-902-RH 30 reactions
EUR 446

Serum, Monkey, Cynomolgus
MBS638784-10mL 10mL
EUR 435

Serum, Monkey, Cynomolgus
MBS638784-25mL 25mL
EUR 785

Serum, Monkey, Cynomolgus
MBS638784-50mL 50mL
EUR 1320

Serum, Monkey, Cynomolgus
MBS638784-5x50mL 5x50mL
EUR 5710

Biotinylated Recombinant Cynomolgus MSLN/Mesothelin Protein (Primary Amine Labeling)
RP02749 100μg
EUR 1423.5
  • Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glyc
  • Show more

Monkey Prostate cDNA-Random Primer, Cynomolgus
KD-408-RH 30 reactions
EUR 316

Cryo Monkey (Rhesus) Hepatocytes, Plateable
LORHCP01 each
EUR 965.52

Monkey Esophagus cDNA-Random Primer, Cynomolgus
KD-301-RH 30 reactions
EUR 316

Monkey Pituitary cDNA-Random Primer, Cynomolgus
KD-502-RH 30 reactions
EUR 446

Monkey Diaphragm cDNA-Random Primer, Cynomolgus
KD-605-RH 30 reactions
EUR 316

Cryo monkey (Rhesus) Hepatocytes, Suspension
LORHCS01 each
EUR 517.8

Monkey Epididymis cDNA-Random Primer, Cynomolgus
KD-402-RH 30 reactions
EUR 316

Biotinylated Cynomolgus CD24 Protein, Fc Tag, ultra sensitivity (primary amine labeling)
CD4-C8254 25ug
EUR 1647.8
  • CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-ancho
  • Show more
Description: Biotinylated Cynomolgus CD24, Fc Tag, primary amine labeling (CD4-C8254) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Lys 54 (Accession # I7GKK1-1).

Monkey Lymph nodes cDNA-Random Primer, Cynomolgus
KD-703-RH 30 reactions
EUR 446

Monkey Bone Marrow cDNA-Random Primer, Cynomolgus
KD-704-RH 30 reactions
EUR 446

Monkey Adipose Tissue cDNA-Random Primer, Cynomolgus
KD-103-RH 30 reactions
EUR 446

Monkey Salivary Gland, cDNA-Random Primer, Cynomolgus
KD-317-RH 30 reactions
EUR 316

Immortalized Monkey Hepatocytes-SV40 T+t
T0074 1x106 cells / 1.0 ml
EUR 3950

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0050 50 ml
EUR 1049.88
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0100 100 ml
EUR 1503.84
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey plasma with heparin
CMPH07-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey plasma with heparin is indicated as RUO. Do not use on humans.

Monkey, Cynomolgus Genomic DNA
GM-140C 0.1mg
EUR 177

Serum, Monkey, Cynomolgus, Female
MBS638816-10mL 10mL
EUR 440

Serum, Monkey, Cynomolgus, Female
MBS638816-25mL 25mL
EUR 870

Serum, Monkey, Cynomolgus, Female
MBS638816-50mL 50mL
EUR 1350

Serum, Monkey, Cynomolgus, Female
MBS638816-5x50mL 5x50mL
EUR 5845

Monkey Skeletal Muscles cDNA-Random Primer, Cynomolgus
KD-102-RH 30 reactions
EUR 316

Monkey Seminal Vesicles cDNA-Random Primer, Cynomolgus
KD-407-RH 30 reactions
EUR 316

Monkey Eye cDNA, Cynomolgus
KD-106 30 reactions
EUR 316

Monkey Lung cDNA, Cynomolgus
KD-601 30 reactions
EUR 316

Monkey (Cynomolgus) Adipose Lysate
21-159 0.1 mg
EUR 468.6
Description: Monkey (Cynomolgus) adipose tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Cynomolgus) adipose tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the adipose tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The adipose tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

OORA01345-10ML - MONKEY (Cynomolgus) PLASMA in Sodium Heparin
OORA01345-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in Sodium Heparin

Monkey Brain, cDNA, Cynomolgus
KD-201 30 reactions
EUR 316

Monkey Colon cDNA, Cynomolgus
KD-311 30 reactions
EUR 316

Monkey Liver cDNA, Cynomolgus
KD-314 30 reactions
EUR 316

Monkey Ovary cDNA, Cynomolgus
KD-406 30 reactions
EUR 316

Monkey Heart cDNA, Cynomolgus
KD-801 30 reactions
EUR 316

Monkey Aorta cDNA, Cynomolgus
KD-807 30 reactions
EUR 446

OORA01469-10ML - MONKEY (Cynomolgus) PLASMA in Lithium Heparin
OORA01469-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) PLASMA in Lithium Heparin

*Monkey Cynomolgus IgG ELISA Kit
IMNCYIGGKT each
EUR 422
  • Wet Ice
Description: *Monkey Cynomolgus IgG ELISA Kit

Monkey Cynomolgus Albumin Purified
IMNCYALB10MG each
EUR 215
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Monkey Cynomolgus Albumin Purified
IMNCYALB25MG each
EUR 475
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Monkey Cynomolgus Albumin Purified
IMNCYALB50MG each
EUR 920
  • Wet Ice
Description: Monkey Cynomolgus Albumin Purified

Monkey Tongue cDNA, Cynomolgus
KD-105 30 reactions
EUR 316

Monkey Rectum cDNA, Cynomolgus
KD-312 30 reactions
EUR 316

Monkey Testis cDNA, Cynomolgus
KD-401 30 reactions
EUR 316

Monkey Spleen cDNA, Cynomolgus
KD-701 30 reactions
EUR 316

Monkey Thymus cDNA, Cynomolgus
KD-702 30 reactions
EUR 316

Monkey Tonsil cDNA, Cynomolgus
KD-707 30 reactions
EUR 446

Monkey Artery cDNA, Cynomolgus
KD-810 30 reactions
EUR 446

Monkey Kidney cDNA, Cynomolgus
KD-901 30 reactions
EUR 316

Cynomolgus Monkey IL13 Protein
E40PM131 20ug
EUR 495

Cynomolgus Monkey TP53 Protein
E40PM135 20ug
EUR 495

Monkey Stomach cDNA, Cynomolgus
KD-302 30 reactions
EUR 316

Monkey Adrenal cDNA, Cynomolgus
KD-501 30 reactions
EUR 446

Monkey Thyroid cDNA, Cynomolgus
KD-503 30 reactions
EUR 446

Monkey Trachea cDNA, Cynomolgus
KD-602 30 reactions
EUR 446

Monkey Bladder cDNA, Cynomolgus
KD-902 30 reactions
EUR 446

Monkey Prostate cDNA, Cynomolgus
KD-408 30 reactions
EUR 316

Rat Liver PrimaCell: Hepatocytes
2-82595 1 Kit Ask for price

Monkey Small Intestine, Ileum cDNA-Random Primer, Cynomolgus
KD-309-RH 30 reactions
EUR 316

Monkey Cynomolgus Skin Genomic DNA
KG-101 0.1mg
EUR 210

Monkey Cynomolgus Lung Genomic DNA
KG-601 0.1mg
EUR 210

Cynomolgus Monkey IGFBP1 Protein
E40PM143 20ug
EUR 495

Monkey Esophagus cDNA, Cynomolgus
KD-301 30 reactions
EUR 316

Monkey Pituitary cDNA, Cynomolgus
KD-502 30 reactions
EUR 446

Monkey Diaphragm cDNA, Cynomolgus
KD-605 30 reactions
EUR 316

Monkey Cynomolgus Brain Genomic DNA
KG-201 0.1mg
EUR 210

Monkey Cynomolgus Colon Genomic DNA
KG-311 0.1mg
EUR 210

Monkey Cynomolgus Liver Genomic DNA
KG-314 0.1mg
EUR 210

Monkey Cynomolgus Ovary Genomic DNA
KG-406 0.1mg
EUR 210

Monkey Cynomolgus Heart Genomic DNA
KG-801 0.1mg
EUR 210

Biotinylated Recombinant Cynomolgus CD3E&CD3D/CD3 epsilon&CD3 delta Protein (Primary Amine Labeling)
RP02748 100μg
EUR 2843.75
  • T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell
  • Show more

Biotinylated Cynomolgus Transferrin R / CD71 Protein, His Tag, ultra sensitivity (primary amine labeling)
TFR-C8249 25ug
EUR 1647.8
  • CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delive
  • Show more
Description: Biotinylated Cynomolgus Transferrin R, His Tag, primary amine labeling (TFR-C8249) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # G8F602-1). It is the biotinylated form of Cynomolgus Transferrin R, His Tag(Cat. No. TFR-C524a).

Monkey Epididymis cDNA, Cynomolgus
KD-402 30 reactions
EUR 316

Mouse Liver PrimaCell: Hepatocytes
2-82100 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes
2-96121 1 Kit Ask for price

Monkey Small Intestine, Jejunum cDNA-Random Primer, Cynomolgus
KD-308-RH 30 reactions
EUR 316

Monkey Eye Total RNA, Cynomolgus
KR-106 0.025mg
EUR 195

Monkey Cynomolgus Testis Genomic DNA
KG-401 0.1mg
EUR 210

Monkey Cynomolgus Uterus Genomic DNA
KG-411 0.1mg
EUR 210

Monkey Cynomolgus Spleen Genomic DNA
KG-701 0.1mg
EUR 210

Monkey Cynomolgus Kidney Genomic DNA
KG-901 0.1mg
EUR 210

Monkey Cynomolgus Lung Tissue Lysate
IMNCYLGTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Lung Tissue Lysate

Monkey Cynomolgus Skin Tissue Lysate
IMNCYSKNTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Skin Tissue Lysate

Monkey Cynomolgus Lung Tissue Lysate
MBS8420208-INQUIRE INQUIRE Ask for price

Monkey Cynomolgus Skin Tissue Lysate
MBS8420210-INQUIRE INQUIRE Ask for price

Monkey Small Intestine, Duodenum cDNA-Random Primer, Cynomolgus
KD-307-RH 30 reactions
EUR 316

Monkey Cynomolgus Stomach Genomic DNA
KG-302 0.1mg
EUR 210

Monkey Cynomolgus Colon Tissue Lysate
IMNCYCLNTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Colon Tissue Lysate

Monkey Cynomolgus Colon Tissue Lysate
MBS8420204-INQUIRE INQUIRE Ask for price

Monkey Skin Total RNA, Cynomolgus
KR-101 0.05mg
EUR 195

Monkey Lung Total RNA, Cynomolgus
KR-601 0.1mg
EUR 195

Monkey Cynomolgus Pancreas Genomic DNA
KG-313 0.1mg
EUR 210

Monkey Cynomolgus Kidney Tissue Lysate
IMNCYKDTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Kidney Tissue Lysate

Monkey Cynomolgus Spleen Tissue Lysate
IMNCYSPTL100UG each
EUR 541
  • Wet Ice
Description: Monkey Cynomolgus Spleen Tissue Lysate

Monkey Cynomolgus Kidney Tissue Lysate
MBS8420207-INQUIRE INQUIRE Ask for price

Monkey Cynomolgus Spleen Tissue Lysate
MBS8420211-INQUIRE INQUIRE Ask for price

Monkey Brain Total RNA, Cynomolgus
KR-201 0.1mg
EUR 195

Monkey Colon Total RNA, Cynomolgus
KR-311 0.1mg
EUR 195

Monkey Liver Total RNA, Cynomolgus
KR-314 0.1mg
EUR 195

Monkey Ovary Total RNA, Cynomolgus
KR-406 0.05mg
EUR 195

Monkey Heart Total RNA, Cynomolgus
KR-801 0.05mg
EUR 195

Monkey Aorta Total RNA, Cynomolgus
KR-807 0.025mg
EUR 260

Monkey Cynomolgus Esophagus Genomic DNA
KG-301 0.1mg
EUR 210

Monkey Cynomolgus Intestine Genomic DNA
KG-306 0.1mg
EUR 210

Monkey Cynomolgus Adipose Tissue Lysate
IMNCYADPTTL100UG each
EUR 804
  • Wet Ice
Description: Monkey Cynomolgus Adipose Tissue Lysate

*Monkey Cynomolgus IgG Affinity Purified
IMNCYIGGAP10MG each
EUR 300
  • Dry Ice
Description: *Monkey Cynomolgus IgG Affinity Purified

*Monkey Cynomolgus IgG Affinity Purified
IMNCYIGGAP50MG each
EUR 706
  • Dry Ice
Description: *Monkey Cynomolgus IgG Affinity Purified

Monkey Cynomolgus Adipose Tissue Lysate
MBS8420202-INQUIRE INQUIRE Ask for price

Monkey Tongue Total RNA, Cynomolgus
KR-105 0.05mg
EUR 195

Monkey Rectum Total RNA, Cynomolgus
KR-312 0.1mg
EUR 195

Monkey Testis Total RNA, Cynomolgus
KR-401 0.05mg
EUR 195

Monkey Spleen Total RNA, Cynomolgus
KR-701 0.1mg
EUR 195

Monkey Thymus Total RNA, Cynomolgus
KR-702 0.05mg
EUR 195

Monkey Tonsil Total RNA, Cynomolgus
KR-707 0.05mg
EUR 260

Monkey Artery Total RNA, Cynomolgus
KR-810 0.025mg
EUR 260

Monkey Kidney Total RNA, Cynomolgus
KR-901 0.1mg
EUR 195

Monkey Lymph nodes cDNA, Cynomolgus
KD-703 30 reactions
EUR 446

Monkey Bone Marrow cDNA, Cynomolgus
KD-704 30 reactions
EUR 446

Monkey (Cynomolgus) Methylated DNA Control
D6534149-Cy 5 ug Ask for price

OORA01366-10ML - MONKEY (Cynomolgus) SERUM
OORA01366-10ML 10mL
EUR 1089
  • MONKEY (Cynomolgus) SERUM

Monkey Cynomolgus IgG1 Affinity Purified
IMNCYIGG1AP1000UG each
EUR 558
  • Dry Ice
Description: Monkey Cynomolgus IgG1 Affinity Purified

Monkey Cynomolgus IgG1 Affinity Purified
IMNCYIGG1AP100UG each
EUR 206
  • Dry Ice
Description: Monkey Cynomolgus IgG1 Affinity Purified

Cynomolgus Monkey CD3D & CD3E Protein
E40PM141 20ug
EUR 495

Cynomolgus Monkey CD3D & CD3E Protein
E40PM142 20ug
EUR 495

Monkey Stomach Total RNA, Cynomolgus
KR-302 0.1mg
EUR 195

Monkey Adrenal Total RNA, Cynomolgus
KR-501 0.025mg
EUR 260

Monkey Thyroid Total RNA, Cynomolgus
KR-503 0.025mg
EUR 260

Monkey Trachea Total RNA, Cynomolgus
KR-602 0.05mg
EUR 260

Monkey Eye Total Protein, Cynomolgus
KT-106 0.5mg
EUR 176

Monkey Tissue cDNA-Random Primer Panel, Cynomolgus, any 10 tissues
KD-010-RH 10x10 reactions
EUR 1529

Biotinylated Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, ultra sensitivity (primary amine labeling)
LA3-C8258 25ug
EUR 1647.8
  • Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intr
  • Show more
Description: Biotinylated Cynomolgus LAG-3, Mouse IgG2a Fc Tag, primary amine labeling (LA3-C8258) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - His 449 (Accession # XP_005570011.1).

Monkey Prostate Total RNA, Cynomolgus
KR-408 0.05mg
EUR 195

Monkey Lung Total Protein, Cynomolgus
KT-601 1mg
EUR 176

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron
SCMPH35-0050 50 ml
EUR 1071.72
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron
SCMPH35-0100 100 ml Ask for price
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron
SCMPH35-0500 500 ml Ask for price
  • Sterile filtered Cynomolgus monkey plasma with heparin, 0.2 micron is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0050 50 ml
EUR 889.2
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0100 100 ml
EUR 1368.12
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Non-sterile Cynomolgus monkey serum
CMS05-0500 500 ml Ask for price
  • Non-sterile Cynomolgus monkey serum is indicated as RUO. Do not use on humans.

Monkey Esophagus Total RNA, Cynomolgus
KR-301 0.05mg
EUR 195

Monkey Pituitary Total RNA, Cynomolgus
KR-502 0.025mg
EUR 260

Monkey Diaphragm Total RNA, Cynomolgus
KR-605 0.05mg
EUR 195

Monkey Brain Total Protein, Cynomolgus
KT-201 1mg
EUR 176
The Nrf2 agonist sulforaphane, which upregulated the transcriptional exercise of the Nrf2-antioxidant response ingredient (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation impact on HSCs. Nonetheless, the liver tissue obtained from non-alcoholic steatohepatitis (NASH) mice with Nrf2 knockdown confirmed decreased antioxidation and vital liver senescence and fibrosis.
In conclusion, this examine confirmed that lipid accumulation induces hepatocyte senescence, which results in HSC activation and improvement of hepatic fibrosis. Growing the exercise of the Nrf2-ARE antioxidant pathway in senescent hepatocytes elicited the other impact, suggesting that focusing on Nrf2 might stop or delay the development of aging-related liver fibrosis in NASH.
Source : Gentaur

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