Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

Iron is important for erythropoiesis and different organic processes, however is poisonous in extra. Dietary absorption of iron is a extremely regulated course of and is a serious determinant of physique iron ranges. Iron excretion, nonetheless, is taken into account a passive, unregulated course of, and the underlying pathways are unknown. Right here we investigated the function of metallic transporters SLC39A14 and SLC30A10 in biliary iron excretion.
Whereas SLC39A14 imports manganese into the liver and different organs beneath physiological circumstances, it imports iron beneath circumstances of iron extra. SLC30A10 exports manganese from hepatocytes into the bile. We hypothesized that biliary excretion of extra iron could be impaired by SLC39A14 and SLC30A10 deficiency.
We due to this fact analyzed biliary iron excretion in Slc39a14- and Slc30a10-deficient mice raised on iron-sufficient and -rich diets. Bile was collected surgically from mice then analyzed with non-heme iron assays, mass spectrometry, ELISAs, and an electrophoretic assay for iron-loaded ferritin. Our outcomes help a mannequin during which biliary excretion of extra iron requires iron import into hepatocytes by SLC39A14, adopted by iron export into bile predominantly as ferritin, with iron export occurring independently of SLC30A10. To our information, that is the primary report of a molecular determinant of mammalian iron excretion, and may function foundation for future investigations into mechanisms of iron excretion and relevance to iron homeostasis.
Rat Cholesterol ELISA ELISA
E01A11128
Goat Cholesterol ELISA ELISA
E01A46041
Mouse Cholesterol ELISA ELISA
E01A19869

Extracellular vesicles activate ATM-Chk2 signaling pathway by the intercellular switch of mitochondrial DNA in HBV-infected human hepatocytes

Hepatitis B virus (HBV) is a human hepatotropic pathogen inflicting hepatocellular carcinoma. We not too long ago obtained HBV-susceptible immortalized human hepatocyte NKNT-Three by exogenously expressing NTCP and its derived cell clones, #28.3.eight and #28.3.25.13 exhibiting totally different ranges of HBV susceptibility.
Within the current research, we confirmed that HBV an infection activated the ATM-Chk2 signaling pathway in #28.3.25.13 cells however not in #28.3.eight cells. Each the cell tradition supernatant and extracellular vesicles (EVs) derived from HBV-infected #28.3.25.13 cells additionally activated the ATM-Chk2 signaling pathway in naïve #28.3.25.13 cells.
Curiously, EVs derived from HBV-infected #28.3.25.13 cells included increased stage of mitochondrial DNA (mtDNA) than these from HBV-infected #28.3.eight cells. Primarily based on our outcomes, we suggest the novel mannequin that EVs mediate the activation of ATM-Chk2 signaling pathway by the intercellular switch of mtDNA in HBV-infected human hepatocyte.

Results of Iron Oxide Nanoparticles on Structural Group of Hepatocyte Chromatin: Grey Stage Co-occurrence Matrix Evaluation

Grey stage co-occurrence matrix (GLCM) evaluation is a up to date and progressive computer-based algorithm that can be utilized for the quantification of refined modifications in a mobile construction. On this work, we use this methodology for the detection of discrete alterations in hepatocyte chromatin distribution after in vivo publicity to iron oxide nanoparticles (IONPs). The research was carried out on 40 male, wholesome C57BL/6 mice divided into 4 teams: three experimental teams that acquired totally different doses of IONPs and 1 management group.
We describe the dose-dependent discount of chromatin textural uniformity measured as GLCM angular second second. Related modifications have been detected for chromatin textural uniformity expressed as the worth of inverse distinction second. To the perfect of our information, that is the primary research to research the affect of iron-based nanomaterials on hepatocyte GLCM parameters.
Additionally, that is the primary research to use discrete wavelet rework evaluation, as a supplementary methodology to GLCM, for the evaluation of hepatocyte chromatin construction in these circumstances. The outcomes could current the helpful foundation for future analysis on the applying of GLCM and DWT strategies in pathology and different medical analysis areas.

Selective Imaging of HClO within the Liver Tissue in vivo Utilizing a Close to-infrared Hepatocyte-specific Fluorescent Probe

Liver damage is typified by an inflammatory response. Hypochlorous acid (HClO), an vital endogenous reactive oxygen species, is considered a biomarker related to liver damage. Close to-infrared (NIR) fluorescent probes with the benefit of deep tissue penetrating and low auto-fluorescence interference are extra appropriate for bioimaging in vivo . Thus, on this work, we designed and synthesized a novel NIR hepatocyte-specific fluorescent probe named NHF .
 Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14
The probe NHF confirmed quick response (< 3s), massive spectral variation, and good selectivity to hint HClO in buffer answer. By using N -acetylgalactosamine (parafina) because the concentrating on ligand, probe NHF could be actively delivered to the liver tissue of zebrafish and mice. It’s important that probe NHF is the primary NIR hepatocyte-specific fluorescent probe, which efficiently visualized the up-regulation of endogenous HClO within the oxygen-glucose deprivation/reperfusion (OGD/R) mannequin HepG2 cells and dynamically monitored APAP-induced endogenous HClO within the liver tissue of zebrafish and mice.

Potential protecting impact of hesperidin on hypoxia/reoxygenation-induced hepatocyte damage

Hesperidin (HDN) has been reported to have hydrogen radical- and hydrogen peroxide-removal actions and to serve an antioxidant function in organic techniques. Nonetheless, whether or not HDN protects hepatocytes (HCs) towards hypoxia/reoxygenation (H/R)-induced damage stays unknown. The current research aimed to discover the function of HDN in H/R-induced damage. HCs have been remoted and cultured beneath H/R circumstances with or with out HDN therapy.
HC harm was markedly induced beneath H/R, as indicated by cell viability, supernatant lactate dehydrogenase ranges and alanine aminotransferase ranges; nonetheless, HDN therapy considerably reversed HC damage. Oxidative stress markers (malondialdehyde, superoxide dismutase, glutathioneand reactive oxygen species) have been elevated markedly throughout H/R in HCs; nonetheless, this impact was considerably attenuated after publicity to HDN. In contrast with these of the management group, the mRNA expression ranges of IL-6 and TNF-α in HCs and the concentrations of IL-6 and TNF-α within the supernatants elevated considerably following H/R, and HDN considerably ameliorated these results.

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Plateable

T0118 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Suspension

T0117 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Fischer) Hepatocytes, Plateable

T0108 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Fischer) Hepatocytes, Suspension

T0107 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) hepatocytes, Plateable

T0112 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Plateable

T0106 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Suspension

T0105 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Plateable

T0104 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Suspension

T0103 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Human Hepatocytes

ABC-TC3646 1 vial Ask for price
  • For research use only
Description: The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell transplantation and clinical liver support systems. In appropriate culture condition, cultured human hepatocytes proliferate and maintain differentiated hepatocyte function such as the synthesis of serum proteins. HH from Gentaur Research Laboratories are isolated from human liver. HH are cryopreserved immediately after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HH are characterized by immunofluorescent method with antibodies to albumin, cytokeratin-18 and vimentin. HH are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HH is not recommended for expanding or long term cultures since the cells do not proliferate in culture.

Human Hepatocytes

HC4230 500,000 Cells
EUR 991.2

Human Hepatocytes

CSC-C1495 One Frozen vial Ask for price

Human Hepatocytes

ALHE33 1ml frozen Vial
EUR 620

Rat Liver PrimaCell: Normal Hepatocytes Growth Medium

9-25095 5 x 100 ml Ask for price

Immortalized human hepatocytes

ABI-TC3500 1 vial Ask for price
Description: The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Hepatocytes - Opioid Addicted

HC4230OP 500000
EUR 1148.4

Human Hepatocytes - Opioid Addicted

HC4230OP-B each
EUR 805.5

Human Hepatocytes - Alcohol Addicted

HC4230AA 500,000 Cells
EUR 1148.4

Human Hepatocytes - Alcohol Addicted

HC4230AA-B each
EUR 625.5

Immortalized Human Hepatocytes - Ras

T0059 1x106 cells / 1.0 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-47121 1 Set Ask for price

Human iPSC-derived Hepatocytes

CSC-00863L One Frozen vial Ask for price
  • iPSC-derived Cells

Immortalized Human Hepatocytes - hTERT

T0058 1x106 cells / 1.0 ml Ask for price

Immortalize Human Hepatocytes-SV40

CSC-I9016L One Frozen vial Ask for price

Human Fresh Hepatocytes, Suspension

ABC-TC3432 1 vial Ask for price
  • For research use only
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies.

Human Pooled Hepatocytes(Heps 10)

ABC-TC3458 1 vial Ask for price
  • For research use only
Description: Human Pooled Primary Hepatocytes (Heps) provide an ideal culture model for drug testing and drug development.Heps 20 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 20 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Pooled Hepatocytes(Heps 20)

ABC-TC3459 1 vial Ask for price
  • For research use only
Description: Human Pooled Primary Hepatocytes (HP2 Heps) provide an ideal culture model for drug testing and drug development. HP2 10 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 10 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Hepatocytes-Single Donor, Male

ABC-TC3649 1 vial Ask for price
  • For research use only
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s - single donor, male) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Human Hepatocytes-Single Donor, Female

ABC-TC3647 1 vial Ask for price
  • For research use only
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Rat Hepatocytes

ABC-TC4136 1 vial Ask for price
  • For research use only
Description: Rat Hepatocytes (RH) are isolated from adult rat livers. They are cryopreserved at the end of primary cell isolation.

Mouse Hepatocytes

ABC-TC3928 1 vial Ask for price
  • For research use only
Description: Our High Quality Mouse Hepatocytes have been isolated from mouse livers after liver perfusion and low-speed differential centrifugation. The hepatocytes are cryoperserved immediately after the experimental process and delivered frozen.

Human Mature Hepatocytes, Non-Plateable

ABC-TC3893 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Bovine Hepatocytes

ABC-TC3132 1 vial Ask for price
  • For research use only
Description: Bovine hepatocytes, 4-week bovine

MCHT50 - Cryo Human Hepatocytes thawing media

LOMCHT50 each
EUR 102.95

HighQC™ Human IPSC-Derived Hepatocytes

ABC-SC2119 1 vial Ask for price
Description: These hepatocytes overcome the functionality, reproducibility, and availability limitations of existing primary cell and tumor-derived cell models by providing the following:Relevant hepatic functionality and phenotypic stabilityExpression of clinical targets that are relevant for liver and metabolic diseaseCompatibility with a wide range of 3D and microphysiological systemsQuality-controlled manufacturing and batch reproducibilityReady supply in a cryopreserved format

Human Hepatocytes-Single Donor, Male; Inducible

ABC-TC3650 1 vial Ask for price
  • For research use only
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, male) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Human Plateable Hepatocytes From Whole Livers

ABC-TC4022 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Human Hepatocytes-Single Donor, Female; Inducible

ABC-TC3648 1 vial Ask for price
  • For research use only
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat

4-20302 ea Ask for price

Immortalized Human Hepatocytes - HPVE6/E7 and Myc

T0057 1x10^6 cells / 1.0 ml
EUR 350

Human hepatocytes in suspension , 10 million cells

LOHUFS10-EU each Ask for price

Rabbit Liver Hepatocytes

ABC-TC4061 1 vial Ask for price
  • For research use only
Description: Rabbit liver epithelial cells, 5-week rabbit

Rat Plateable Hepatocytes

ABC-TC4024 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Plateable Mouse Hepatocytes

ABC-TC4023 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-33100 1 Set Ask for price

Immortalized Monkey Hepatocytes

CSC-I2072Z One Frozen vial Ask for price

Immortalized Human Hepatocytes - HPV E6/E7, hTERT & MycT58A

T0063 1x10^6 cells / 1.0 ml
EUR 350

Human Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80314 1 x 100 ml Ask for price

Plateable DOG (Beagle) Hepatocytes

ABC-TC4021 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Immortalized Rat Hepatocytes - SV40

T0078 1x106 cells / 1.0 ml
EUR 3950

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
  • For research use only
Description: Rat Hepatocytes Suspension - Adult

Immortalized Mouse Hepatocytes - SV40

T0101 1x106 cells / 1.0 ml
EUR 3950

Immortalized Hamster Hepatocytes (SV40)

T0072 1x10^6 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes-SV40

CSC-I2205Z One Frozen vial Ask for price

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml
EUR 3950

Cryo Dog (Beagle) Hepatocytes, Plateable

LODBCP01 each
EUR 1002.34

Cryo Rat (Wistar) Hepatocytes, Plateable

LORICP01 each
EUR 552.24

Cryo Monkey (Cyno) Hepatocytes, Plateable

LOCYCP01 each
EUR 965.52

Cryo Dog (Beagle) Hepatocytes, Suspension

LODBCS01 each
EUR 390.63

Cryo Rat (Wistar) Hepatocytes, Suspension

LORICS01 each
EUR 328.97

Cryo Monkey (Cyno) Hepatocytes, Suspension

LOCYCS01 each
EUR 517.8

HighQC™ Mouse Hepatocytes Stem Cell

ABC-SC0041 1 vial Ask for price
Description: Mouse Hepatocyte Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Cryo Mouse (CD-1) Hepatocytes, Pltable

LOMCCP01 each
EUR 1102.09

Cryo Monkey (Rhesus) Hepatocytes, Plateable

LORHCP01 each
EUR 965.52

Cryo monkey (Rhesus) Hepatocytes, Suspension

LORHCS01 each
EUR 517.8

Human hepatocytes in monolayer-long term cultures, in 6 well-plate

LOHUF06-EU each Ask for price

Human hepatocytes in monolayer-long term cultures, in 12 well-plate

LOHUF12-EU each Ask for price

Human hepatocytes in monolayer-long term cultures, in 24 well-plate

LOHUF24-EU each Ask for price

Human hepatocytes in monolayer-long term cultures, in 48 well-plate

LOHUF48-EU each Ask for price

Human hepatocytes in monolayer-long term cultures, in 96 well-plate

LOHUF96-EU each Ask for price

Immortalized Sprague Dawley Rats Hepatocytes

ABI-TC047D 1 vial Ask for price
Description: Sprague Dawley rats hepatocytes conditionally Immortalised with temperature sensitive SV40 large T antigen.

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml
EUR 3950

C57BL/6 Mouse Hepatocytes Suspension-Adult

ABC-TC3192 1 vial Ask for price
  • For research use only
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult

Cryo Rat (Sprague Dawley) Hepatocytes, Plateable

LORSCP01 each
EUR 552.24

Immortalized Hamster Hepatocytes-SV40 T+t

T0071 1x106 cells / 1.0 ml
EUR 3950

Liver Dissociation System 1 (Hepatocytes), Mouse

4-20301 ea Ask for price

Cryo Rat (Sprague Dawley) Hepatocytes, Suspension

LORSCS01 each
EUR 328.97

Cryo Rat (Wistar Hannover) Hepatocytes, Plateable

LORWCP01 each
EUR 552.24

Male Beagle dog HEPATOCYTES , 10 million cells

LODBFS10-EU each Ask for price

Wistar male rat HEPATOCYTES , 10 million cells

LORIFS10-EU each Ask for price

Conditionally Immortalized Rat Hepatocytes-SV40T

CSC-I2094Z One Frozen vial Ask for price

Cryo Rat (Wistar Hannover) Hepatocytes, Suspension

LORWCS01 each
EUR 328.97

Immortalized Mouse Hepatocytes-Conditionally (ImHep)

T0099 1x106 cells / 1.0 ml
EUR 3950

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Male Cynomolgus monkey HEPATOCYTES , 10 million cells

LOCYFS10-EU each Ask for price

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80322 1 x 100 ml Ask for price

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80306 1 x 100 ml Ask for price

Hepatocytes of male Beagle dog in monolayer, in 6 well-plate

LODBF06-EU each Ask for price

Hepatocytes of male Beagle dog in monolayer, in 12 well-plate

LODBF12-EU each Ask for price

Hepatocytes of male Beagle dog in monolayer, in 24 well-plate

LODBF24-EU each Ask for price

Hepatocytes of male Beagle dog in monolayer, in 48 well-plate

LODBF48-EU each Ask for price

Hepatocytes of male Beagle dog in monolayer, in 96 well-plate

LODBF96-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 6 well-plate

LORIF06-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 12 well-plate

LORIF12-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 24 well-plate

LORIF24-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 48 well-plate

LORIF48-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 96 well-plate

LORIF96-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 6 well-plate

LOCYF06-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 12 well-plate

LOCYF12-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 24 well-plate

LOCYF24-EU each Ask for price

Male Cynomolgus monkey HEPATOCYTES in monolayer, in 48 well-plate

LOCYF48-EU each Ask for price

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat

4-20306 ea Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 6 well plate

LORSF06-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 12 well plate

LORSF12-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 24 well plate

LORSF24-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 48 well plate

LORSF48-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 96 well plate

LORSF96-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in suspension , 10 million cells

LORSFS10-EU each Ask for price

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat

4-20303 ea Ask for price

Human Primary hepatic carcinoma ELISA kit

E01A7068 96T
EUR 700
Description: ELISA

Human Primary hepatic carcinoma ELISA kit

E01P0656-192T 192 tests
EUR 1524
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-48 1 plate of 48 wells
EUR 624
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA kit

E01P0656-96 1 plate of 96 wells
EUR 822
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Primary hepatic carcinoma ELISA Kit

MBS726869-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Primary hepatic carcinoma ELISA Kit

MBS726869-48StripWells 48-Strip-Wells
EUR 485

Human Primary hepatic carcinoma ELISA Kit

MBS726869-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Primary hepatic carcinoma ELISA Kit

MBS726869-96StripWells 96-Strip-Wells
EUR 690

Normal Human Primary Hepatic Kupffer Cells

T5549 1x10^6 cells / 1.0 ml
EUR 1115

Normal Human Primary Hepatic Stellate Cells

T5546 1x10^6 cells / 1.0 ml
EUR 1175

Human Primary Hepatic Non-Parenchymal Cells

T4061 5x10^5 cells / 1.0 ml Ask for price

Human primary hepatic carcinoma,PHC ELISA Kit

YLA2711HU-48T 48T Ask for price

Human primary hepatic carcinoma,PHC ELISA Kit

YLA2711HU-96T 96T Ask for price

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-48Tests 48 Tests Ask for price

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-96Tests 96 Tests
EUR 388

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-48T 48T
EUR 346.8

Human primary hepatic carcinoma(PHC)ELISA Kit

GA-E1689HM-96T 96T
EUR 559.2

Human primary hepatic carcinoma(PHC)ELISA Kit

QY-E03406 96T
EUR 433.2

Human primary hepatic carcinoma,PHC ELISA Kit

SL1444Hu 96 Tests
EUR 468
  • 2-8°C

Human primary hepatic carcinoma (PHC) ELISA Kit

MBS2613515-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human primary hepatic carcinoma (PHC) ELISA Kit

MBS2613515-48StripWells 48-Strip-Wells
EUR 285

Human primary hepatic carcinoma (PHC) ELISA Kit

MBS2613515-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human primary hepatic carcinoma (PHC) ELISA Kit

MBS2613515-96StripWells 96-Strip-Wells
EUR 405

Human primary hepatic carcinoma,PHC ELISA Kit

201-12-1673 96 tests
EUR 528
  • This primary hepatic carcinoma ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human primary hepatic carcinoma(PHC) ELISA Kit

EIA07811h each
EUR 430

Human Primary Hepatic Sinusoidal Endothelial Cells

T4220 5x10^5 cells / 1.0 ml
EUR 975

Primary Rat Hepatic Stellate Cells (HSC)

CSI071Ra01 5X10^5
EUR 880
  • Rat

Rat Primary hepatic carcinoma ELISA kit

E02P0656-192T 192 tests
EUR 1524
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-48 1 plate of 48 wells
EUR 624
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E02P0656-96 1 plate of 96 wells
EUR 822
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-192T 192 tests
EUR 1524
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-48 1 plate of 48 wells
EUR 624
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Primary hepatic carcinoma ELISA kit

E07P0656-96 1 plate of 96 wells
EUR 822
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-192T 192 tests
EUR 1524
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-48 1 plate of 48 wells
EUR 624
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Primary hepatic carcinoma ELISA kit

E08P0656-96 1 plate of 96 wells
EUR 822
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine Primary hepatic carcinoma in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Primary hepatic carcinoma ELISA kit

E01A15814 96T
EUR 700
Description: ELISA

Rat Primary hepatic carcinoma ELISA Kit

MBS731505-10x96StripWells 10x96-Strip-Wells
EUR 5685

Rat Primary hepatic carcinoma ELISA Kit

MBS731505-48StripWells 48-Strip-Wells
EUR 485
Western blotting demonstrated that microtubule-associated protein 1 gentle chain 3α (MAP1LC3A, also called LC3) and Beclin-1 protein expression ranges elevated, whereas sequestosome 1 ranges decreased throughout H/R following publicity to HDN. The variety of GFP-LC3 puncta in HCs following publicity to HDN was elevated in contrast with that noticed in HCs with out HDN publicity beneath the H/R circumstances after bafilomycin A1 therapy. In abstract, the current research demonstrated that HDN attenuated HC oxidative stress and inflammatory responses whereas enhancing autophagy throughout H/R. HDN could have a possible protecting impact on HCs throughout H/R-induced damage.
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