Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

Ammonia has a cytotoxic impact and may due to this fact be used as a range agent for enrichment of zone I hepatocytes. Nevertheless, it has not but been decided whether or not ammonia-treated hepatocyte-like cells are capable of proliferate in vitro. On this research, we employed an ammonia choice technique to purify hepatocyte-like cells that had been differentiated from human embryonic stem cells (ESCs) and from induced pluripotent stem cells (iPSCs).
The resistance to cytotoxicity or cell loss of life by ammonia is probably going attributable to the metabolism of ammonia within the cells. Along with ammonia metabolism-related genes, ammonia-selected hepatocytes confirmed elevated expression of the cytochrome P450 genes. Moreover, the ammonia-selected cells achieved immortality or at the very least an equal life span to human pluripotent stem cells with out affecting expression of the liver-associated genes. Ammonia remedy together with in vitro propagation is helpful for acquiring massive portions of hepatocytes.

BAM15, a Mitochondrial Uncoupling Agent, Attenuates Irritation within the LPS Injection Mouse Mannequin: An Adjunctive Anti-Irritation on Macrophages and Hepatocytes

Controlof immune responses by means of the immunometabolism interference is attention-grabbing for sepsis remedy. Then, expression of immunometabolism-associated genes and BAM15, a mitochondrial uncoupling agent, was explored in a proinflammatory mannequin utilizing lipopolysaccharide (LPS) injection. Accordingly, the decreased expression of mitochondrial uncoupling proteins was demonstrated by transcriptomic evaluation on metabolism-associated genes in macrophages (RAW246.7) and by polymerase chain response in LPS-stimulated RAW246.7 and hepatocytes (Hepa 1-6).
Pretreatment with BAM15 at 24 h previous to LPS in macrophages attenuated supernatant inflammatory cytokines (IL-6, TNF-α, and IL-10), downregulated genes of proinflammatory M1 polarization (iNOS and IL-1β), upregulated anti-inflammatory M2 polarization (Arg1 and FIZZ), and decreased cell power standing (extracellular flux evaluation and ATP manufacturing). Likewise, BAM15 decreased expression of proinflammatory genes (IL-6, TNF-α, IL-10, and iNOS) and diminished cell power in hepatocytes. In LPS-administered mice, BAM15 attenuated serum cytokines, organ damage (liver enzymes and serum creatinine), and tissue cytokines (livers and kidneys), partially, by means of the improved phosphorylated αAMPK, a sensor of ATP depletion with anti-inflammatory property, within the liver, and diminished inflammatory monocytes/macrophages (Ly6C +ve, CD11b +ve) within the liver as detected by Western blot and circulate cytometry, respectively. In conclusion, a proof of idea for irritation attenuation of BAM15 by means of metabolic interference-induced anti-inflammation on macrophages and hepatocytes was demonstrated as a brand new technique of anti-inflammation in sepsis.

[Establishment and evaluation of hepatocyte injury model induced by LPS/D-galactosamine in vitro]

Goal To ascertain a novel hepatocyte damage mannequin induced by lipopolysaccharide/D-galactosamine (LPS/D-GalN) in vitro. Strategies Freshly remoted mouse main hepatocytes had been cultured in vitro and handled with totally different doses of tumor necrosis factor-α (TNF-α) and 5 mg/mL of D-GalN. The supernatants from hepatocyte tradition had been detected for alanine aminotransferase (ALT) exercise by chemiluminescence assay.
Bone marrow-derived macrophages (BMDMs) had been stimulated with 1 μg/mL of LPS and the extent of TNF-α in supernatants had been detected by ELISA. Main hepatocytes had been handled with the BMDM supernatants mixed with 5 mg/mL D-GalN or 50 ng/mL actinomycin D (ActD) for 24 hours. The extent of ALT from hepatocyte supernatant was detected and morphology of hepatocytes was noticed with microscopy.
 Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells
BMDMs and hepatocytes had been co-cultured and handled with 1 μg/mL of LPS mixed with D-GalN or ActD for 24 hours. Hepatocyte damage was mirrored by the ALT exercise and hepatocyte morphology. Outcomes The ALT exercise was considerably elevated within the supernatants of hepatocytes handled with TNF-α and D-GalN, indicating the plain hepatocyte damage. Co-treatment with LPS-primed BMDM supernatants and D-GalN or ActD may trigger hepatocyte damage, as mirrored by markedly elevated ALT exercise and the deformed and cracked hepatocytes. Within the context of co-culture of BMDM and hepatocytes, remedy with LPS and D-GalN led to apparent hepatocyte damage as anticipated.
LPS mixed with ActD couldn’t trigger hepatocyte damage, because the BMDMs began to die sooner than they may secret TNF-α to destruct hepatocytes. Hepatocytes with regular morphology and deformed BMDMs had been noticed. Conclusion LPS/D-GalN can be utilized to induce hepatocyte damage in vitro. D-GalN, fairly than ActD, ought to be used as a transcriptional inhibitor when the TNF-α -induced hepatocyte damage is evaluated in a co-culture system of BMDMs and hepatocytes.

Lateral measurement of graphene oxide determines differential mobile uptake and cell loss of life pathways in Kupffer cells, LSECs, and hepatocytes

As a consultant two-dimensional (2D) nanomaterial, graphene oxide (GO) has proven excessive potential in lots of functions attributable to its massive floor space, excessive flexibility, and wonderful dispersibility in aqueous options. These properties make GO a super candidate for bio-imaging, drug supply, and most cancers remedy.
When delivered to the physique, GO has been proven to build up within the liver, the first accumulation web site of systemic supply or secondary unfold from different uptake websites, and induce liver toxicity. Nevertheless, the contribution of the GO physicochemical properties and particular person liver cell varieties to this toxicity is unclear attributable to property variations and various cell varieties within the liver.
Herein, we examine the results of GOs with small (GO-S) and huge (GO-L) lateral sizes in three main cell varieties in liver, Kupffer cells (KCs), liver sinusoidal endothelial cells (LSECs), and hepatocytes. Whereas GOs induced cytotoxicity in KCs, they induced considerably much less toxicity in LSECs and hepatocytes. For KCs, we discovered that GOs had been phagocytosed that triggered NADPH oxidase mediated plasma membrane lipid peroxidation, which results in PLC activation, calcium flux, mitochondrial ROS technology, and NLRP3 inflammasome activation. The following caspase-1 activation induced IL-1β manufacturing and GSDMD-mediated pyroptosis. These results had been lateral size-dependent with GO-L displaying stronger results than GO-S.

Mouse Liver PrimaCell: Normal Hepatocytes Growth Medium

9-32100 5 x 100 ml Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Medium

9-46121 5 x 100 ml Ask for price

Rat Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-26095 1 Set Ask for price

Mouse Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-33100 1 Set Ask for price

Human Liver PrimaCell: Normal Hepatocytes Growth Supplements with Serum (for 500 ml medium)

9-47121 1 Set Ask for price

Rabbit Liver Hepatocytes

ABC-TC4061 1 vial Ask for price
  • For research use only
Description: Rabbit liver epithelial cells, 5-week rabbit

Liver Dissociation System 2 (Hepatocytes, Parenchymal hepatocytes), Mouse and Rat

4-20302 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Rat Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80322 1 x 100 ml Ask for price

Liver Dissociation System 1 (Hepatocytes), Mouse

4-20301 ea Ask for price

Liver Dissociation System 6 (Hepatocytes,Nonparenchymal), Mouse and Rat

4-20306 ea Ask for price

Primary Rat (Fischer) Hepatocytes, Plateable

T0108 5x10^5 cells / 1.0 ml
EUR 1375

Mouse Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80306 1 x 100 ml Ask for price

Human Liver Tissue Preparation Buffer: Normal Hepatocytes

9-80314 1 x 100 ml Ask for price

Primary Rat (Fischer) Hepatocytes, Suspension

T0107 5x10^5 cells / 1.0 ml
EUR 1375

Liver Dissociation System 3 (Hepatocytes, Kupffer, Parenchymal), Mouse and Rat

4-20303 ea Ask for price

Primary Rat (Wistar Han) Hepatocytes, Plateable

T0106 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Wistar Han) Hepatocytes, Suspension

T0105 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Plateable

T0104 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Suspension

T0103 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Plateable

T0118 5x10^5 cells / 1.0 ml
EUR 1375

Primary Dog (Beagle) Hepatocytes, Suspension

T0117 5x10^5 cells / 1.0 ml
EUR 1375

Rat Hepatocytes

ABC-TC4136 1 vial Ask for price
  • For research use only
Description: Rat Hepatocytes (RH) are isolated from adult rat livers. They are cryopreserved at the end of primary cell isolation.

Normal Human Primary Plateable Hepatocytes

T5539 1x10^6 cells / 1.0 ml
EUR 925

Normal Human Primary Plateable Hepatocytes

T5541 1x10^6 cells / 1.0 ml Ask for price

Normal Human Primary Suspension Hepatocytes

T5538 1x10^6 cells / 1.0 ml Ask for price

Primary Mouse (CD-1) Hepatocytes, Plateable

T0120 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (CD-1) Hepatocytes, Suspension

T0119 5x10^5 cells / 1.0 ml
EUR 1375

Human Plateable Hepatocytes From Whole Livers

ABC-TC4022 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Primary Mouse (C57BI/6) Hepatocytes, Plateable

T0122 5x10^5 cells / 1.0 ml
EUR 1375

Primary Mouse (C57BI/6) Hepatocytes, Suspension

T0121 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes - 5 million

T5996 5x10^6 cells / 1.0 ml Ask for price

Primary Monkey (Cynomolgus) hepatocytes, Plateable

T0112 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Enhanced Primary Human Hepatocytes – 1 Million

T5995 1x10^6 cells / 1.0ml Ask for price

Primary Human Hepatocytes, Transporter Uptake Qualified

T0125 5x10^5 cells / 1.0 ml
EUR 3500

Rat Plateable Hepatocytes

ABC-TC4024 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Primary Human Hepatocytes, Induction Qualified, Plateable

T0128 5x10^5 cells / 1.0 ml
EUR 2625

Primary Human Hepatocytes, Metabolism Qualified, Plateable

T0124 5x10^5 cells / 1.0 ml
EUR 2625

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

Immortalized Rat Hepatocytes - SV40

T0078 1x106 cells / 1.0 ml
EUR 3950

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
  • For research use only
Description: Rat Hepatocytes Suspension - Adult

Human Hepatocytes

ABC-TC3646 1 vial Ask for price
  • For research use only
Description: The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell transplantation and clinical liver support systems. In appropriate culture condition, cultured human hepatocytes proliferate and maintain differentiated hepatocyte function such as the synthesis of serum proteins. HH from Gentaur Research Laboratories are isolated from human liver. HH are cryopreserved immediately after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HH are characterized by immunofluorescent method with antibodies to albumin, cytokeratin-18 and vimentin. HH are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HH is not recommended for expanding or long term cultures since the cells do not proliferate in culture.

Mouse Hepatocytes

ABC-TC3928 1 vial Ask for price
  • For research use only
Description: Our High Quality Mouse Hepatocytes have been isolated from mouse livers after liver perfusion and low-speed differential centrifugation. The hepatocytes are cryoperserved immediately after the experimental process and delivered frozen.

Human Hepatocytes

HC4230 500,000 Cells
EUR 991.2

Human Hepatocytes

CSC-C1495 One Frozen vial Ask for price

Human Hepatocytes

ALHE33 1ml frozen Vial
EUR 620

Bovine Hepatocytes

ABC-TC3132 1 vial Ask for price
  • For research use only
Description: Bovine hepatocytes, 4-week bovine

Cryo Rat (Wistar) Hepatocytes, Plateable

LORICP01 each
EUR 552.24

Cryo Rat (Wistar) Hepatocytes, Suspension

LORICS01 each
EUR 328.97

Cryo Rat (Sprague Dawley) Hepatocytes, Plateable

LORSCP01 each
EUR 552.24

Conditionally Immortalized Rat Hepatocytes-SV40T

CSC-I2094Z One Frozen vial Ask for price

Cryo Rat (Sprague Dawley) Hepatocytes, Suspension

LORSCS01 each
EUR 328.97

Cryo Rat (Wistar Hannover) Hepatocytes, Plateable

LORWCP01 each
EUR 552.24

Plateable Mouse Hepatocytes

ABC-TC4023 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Cryo Rat (Wistar Hannover) Hepatocytes, Suspension

LORWCS01 each
EUR 328.97

Wistar male rat HEPATOCYTES , 10 million cells

LORIFS10-EU each Ask for price

Human Cancer PrimaCell10: Liver Tumor Cells

2-96033 1 Kit Ask for price

Immortalized human hepatocytes

ABI-TC3500 1 vial Ask for price
Description: The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.

Immortalized Monkey Hepatocytes

CSC-I2072Z One Frozen vial Ask for price

Plateable DOG (Beagle) Hepatocytes

ABC-TC4021 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Human iPSC-derived Hepatocytes

CSC-00863L One Frozen vial Ask for price
  • iPSC-derived Cells

Human Hepatocytes - Opioid Addicted

HC4230OP 500000
EUR 1148.4

Human Hepatocytes - Opioid Addicted

HC4230OP-B each
EUR 805.5

Human Fresh Hepatocytes, Suspension

ABC-TC3432 1 vial Ask for price
  • For research use only
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies.

Human Hepatocytes - Alcohol Addicted

HC4230AA 500,000 Cells
EUR 1148.4

Human Hepatocytes - Alcohol Addicted

HC4230AA-B each
EUR 625.5

Immortalized Human Hepatocytes - Ras

T0059 1x106 cells / 1.0 ml Ask for price

Human Pooled Hepatocytes(Heps 10)

ABC-TC3458 1 vial Ask for price
  • For research use only
Description: Human Pooled Primary Hepatocytes (Heps) provide an ideal culture model for drug testing and drug development.Heps 20 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 20 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Human Pooled Hepatocytes(Heps 20)

ABC-TC3459 1 vial Ask for price
  • For research use only
Description: Human Pooled Primary Hepatocytes (HP2 Heps) provide an ideal culture model for drug testing and drug development. HP2 10 Human Pooled Primary Hepatocytes contain cryopreserved hepatocytes pooled from 10 different donors and have undergone only one freeze cycle. Pooled hepatocytes provide the genetic diversity necessary for superior reliability and predictability of the metabolic characteristics of a test compound relative to a representative population. Pooled hepatocytes increase experimental control and reduce costs by eliminating the need to conduct redundant experiments necessary to obtain population-based data. Each lot has undergone a single freeze cycle, assuring maximum hepatocyte viability and consistency from donor to donor within the pool.Cell Features:Each donor's hepatocytes have been cryopreserved ONCE immediately after isolation and purification.Pools of 10 or 20 donors are available. Each donor is represented by a statistically significant number of cells relative to the pool.There is extensive quality control providing characterization of viability and enzyme activity from both individual donors and the total pool.Gentaur guarantees performance and quality.Donor information is available.

Immortalized Mouse Hepatocytes - SV40

T0101 1x106 cells / 1.0 ml
EUR 3950

Immortalized Human Hepatocytes - hTERT

T0058 1x106 cells / 1.0 ml Ask for price

Immortalize Human Hepatocytes-SV40

CSC-I9016L One Frozen vial Ask for price

Immortalized Hamster Hepatocytes (SV40)

T0072 1x10^6 cells / 1.0 ml Ask for price

Immortalized Mouse Hepatocytes-SV40

CSC-I2205Z One Frozen vial Ask for price

Human Cancer PrimaCell10: Liver Tumor Cells Growth Medium

9-46033 5 x 100 ml Ask for price

Immortalized Monkey Hepatocytes-SV40

T0073 1x106 cells / 1.0 ml
EUR 3950

Immortalized Sprague Dawley Rats Hepatocytes

ABI-TC047D 1 vial Ask for price
Description: Sprague Dawley rats hepatocytes conditionally Immortalised with temperature sensitive SV40 large T antigen.

Human Hepatocytes-Single Donor, Male

ABC-TC3649 1 vial Ask for price
  • For research use only
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s - single donor, male) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Cryo Dog (Beagle) Hepatocytes, Plateable

LODBCP01 each
EUR 1002.34

Cryo Monkey (Cyno) Hepatocytes, Plateable

LOCYCP01 each
EUR 965.52

Cryo Dog (Beagle) Hepatocytes, Suspension

LODBCS01 each
EUR 390.63

Human Hepatocytes-Single Donor, Female

ABC-TC3647 1 vial Ask for price
  • For research use only
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Cryo Monkey (Cyno) Hepatocytes, Suspension

LOCYCS01 each
EUR 517.8

HighQC™ Mouse Hepatocytes Stem Cell

ABC-SC0041 1 vial Ask for price
Description: Mouse Hepatocyte Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Cryo Mouse (CD-1) Hepatocytes, Pltable

LOMCCP01 each
EUR 1102.09

Human Mature Hepatocytes, Non-Plateable

ABC-TC3893 1 vial Ask for price
  • For research use only
Description: Gentaur offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Progenitors and Intra-hepatic biliary epithelial cells. We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request.

Cryo Monkey (Rhesus) Hepatocytes, Plateable

LORHCP01 each
EUR 965.52

Rat Bone PrimaCell: Normal Osteoblasts

2-82510 1 Kit Ask for price

Rat Heart PrimaCell 6: Cardiomyocytes

2-82593 1 Kit Ask for price

Cryo monkey (Rhesus) Hepatocytes, Suspension

LORHCS01 each
EUR 517.8

HighQC™ Human IPSC-Derived Hepatocytes

ABC-SC2119 1 vial Ask for price
Description: These hepatocytes overcome the functionality, reproducibility, and availability limitations of existing primary cell and tumor-derived cell models by providing the following:Relevant hepatic functionality and phenotypic stabilityExpression of clinical targets that are relevant for liver and metabolic diseaseCompatibility with a wide range of 3D and microphysiological systemsQuality-controlled manufacturing and batch reproducibilityReady supply in a cryopreserved format

Hepatocytes of male Wistar rat in monolayer, in 6 well-plate

LORIF06-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 12 well-plate

LORIF12-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 24 well-plate

LORIF24-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 48 well-plate

LORIF48-EU each Ask for price

Hepatocytes of male Wistar rat in monolayer, in 96 well-plate

LORIF96-EU each Ask for price

MCHT50 - Cryo Human Hepatocytes thawing media

LOMCHT50 each
EUR 102.95

Immortalized Monkey Hepatocytes-SV40 T+t

T0074 1x106 cells / 1.0 ml
EUR 3950

C57BL/6 Mouse Hepatocytes Suspension-Adult

ABC-TC3192 1 vial Ask for price
  • For research use only
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult

Immortalized Hamster Hepatocytes-SV40 T+t

T0071 1x106 cells / 1.0 ml
EUR 3950

Male Beagle dog HEPATOCYTES , 10 million cells

LODBFS10-EU each Ask for price

Human Hepatocytes-Single Donor, Male; Inducible

ABC-TC3650 1 vial Ask for price
  • For research use only
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, male) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Immortalized Mouse Hepatocytes-Conditionally (ImHep)

T0099 1x106 cells / 1.0 ml
EUR 3950

Human Hepatocytes-Single Donor, Female; Inducible

ABC-TC3648 1 vial Ask for price
  • For research use only
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Rat Bone Marrow PrimaCell: Hematopoietic Cells

2-82590 1 Kit Ask for price

Immortalized Human Hepatocytes - HPVE6/E7 and Myc

T0057 1x10^6 cells / 1.0 ml
EUR 350

Hepatocytes of male Sprague Dawley rat in monolayer, in 6 well plate

LORSF06-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 12 well plate

LORSF12-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 24 well plate

LORSF24-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 48 well plate

LORSF48-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in monolayer, in 96 well plate

LORSF96-EU each Ask for price

Hepatocytes of male Sprague Dawley rat in suspension , 10 million cells

LORSFS10-EU each Ask for price

Rat Thyroid PrimaCell: Thyroid Epithelial Cells

2-82598 1 Kit Ask for price

Human hepatocytes in suspension , 10 million cells

LOHUFS10-EU each Ask for price

Rat Pancreas PrimaCell: Normal Pancreatic Islets

2-82578 1 Kit Ask for price

Male Cynomolgus monkey HEPATOCYTES , 10 million cells

LOCYFS10-EU each Ask for price

Rat Bone Joint PrimaCell: Normal Synovial Cells

2-82509 1 Kit Ask for price

Rat Kidney PrimaCell 6: Proximal Tubular Cells

2-82594 1 Kit Ask for price

Rat Cartilage PrimaCell: Normal Articular Cartilage

2-82523 1 Kit Ask for price

Rat Glomerular PrimaCell: Glomerular Endothelial Cells

2-82592 1 Kit Ask for price

Immortalized Human Hepatocytes - HPV E6/E7, hTERT & MycT58A

T0063 1x10^6 cells / 1.0 ml
EUR 350

Rat Bone PrimaCell: Normal Osteoblasts Growth Medium

9-25010 5 x 100 ml Ask for price

Rat Aorta PrimaCell: Normal Aortic Endothelial Cells

2-82504 1 Kit Ask for price
Amongst the liver cell varieties, decreased cell affiliation and the absence of lipid peroxidation resulted in low cytotoxicity in LSECs and hepatocytes. Utilizing further GO samples with totally different lateral sizes, floor functionalities, or thickness, we additional confirmed the differential cytotoxic results in liver cells and the key position of GO lateral measurement in KUP5 pyroptosis by correlation research. These findings delineated the GO results on mobile uptake and cell loss of life pathways in liver cells, and supply useful data to additional consider GO results on the liver for biomedical functions.
Source : Gentaur

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