Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

Within the liver, the bile canaliculi of hepatocytes are linked to intrahepatic bile ducts lined with cholangiocytes, which take away cytotoxic bile from the liver tissue. Though liver organoids have been reported, it isn’t clear

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Within the liver, the bile canaliculi of hepatocytes are linked to intrahepatic bile ducts lined with cholangiocytes, which take away cytotoxic bile from the liver tissue. Though liver organoids have been reported, it isn’t clear

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Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood.

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Parenteral nutrition-associated cholestasis (PNAC) considerably limits the security of intravenous parenteral diet (PN). Critically ailing infants are extremely weak to PNAC-related morbidity and mortality, nonetheless the impression of hepatic immaturity on PNAC is poorly understood.

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